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dc.contributor.authorSteptoe, Andrew
dc.contributor.authorHamer, Mark
dc.contributor.authorLin, Jue
dc.contributor.authorBlackburn, Elizabeth
dc.contributor.authorErusalimsky, Jorge
dc.contributor.othercmet = Jorge Erusalimsky
dc.date.accessioned2017-01-17T15:35:30Z
dc.date.available2017-01-17T15:35:30Z
dc.date.issued2017-03-01
dc.identifier.citationSteptoe, A., Hamer, M., Lin, J., Blackburn, E. and Erusalimsky, J. (2017) 'The longitudinal relationship between cortisol responses to mental stress and leukocyte telomere attrition', Journal of Clinical Endocrinology and Metabolism, 102(3), pp.962-969. doi: 10.1210/jc.2016-3035en_US
dc.identifier.issn0021-972X
dc.identifier.urihttp://hdl.handle.net/10369/8304
dc.descriptionThis article was published in Journal of Clinical Endocrinology and Metabolism on 14 December 2016 (online), available at http://dx.doi.org/10.1210/jc.2016-3035en_US
dc.description.abstractContext: Chronic psychological stress has been associated with shorter telomeres in some studies, but the underlying mechanisms are poorly understood. One possibility is that the neuroendocrine responses associated with stress exposure are involved. Objective: To testing the hypothesis that greater cortisol responsivity to acute stressors predicts more rapid telomere attrition. Design: We measured salivary cortisol responses to two challenging behavioral tasks. Leukocyte telomere length was measured at the time of mental stress testing and 3 years later. Participants: We studied 411 initially healthy men and women aged 54-76 years. Main outcome measure: Leukocyte telomere length. Results: Cortisol responses to this protocol were small, we divided participants into cortisol responders (n = 156) and non-responders (n = 255) using a criterion (≥20%) previously shown to predict increases in cardiovascular disease risk. There was no significant association between cortisol responsivity and baseline telomere length, although cortisol responders tended to have somewhat shorter telomeres (β = -0.061, standard error 0.049). But cortisol responders had shorter telomeres and more rapid telomere attrition than non-responders on follow-up, after controlling statistically for age, gender, socioeconomic status, smoking, time of day of stress testing and baseline telomere length (β = - 0.10, standard error 0.046, p = 0.029). The association was maintained after additional control for cardiovascular risk factors (β = -0.11, p = 0.031). The difference between cortisol responders and nonresponders was equivalent to approximately 2 years in aging. Conclusions: These findings suggest that cortisol responsivity may mediate in part the relationship between psychological stress and cellular aging.en_US
dc.language.isoenen_US
dc.publisherEndocrine Societyen_US
dc.relation.ispartofseriesJournal of Clinical Endocrinology and Metabolism;
dc.subjectcortisolen_US
dc.subjectmental stressen_US
dc.subjectleukocyteen_US
dc.subjecttelomereen_US
dc.subjectattritionen_US
dc.titleThe longitudinal relationship between cortisol responses to mental stress and leukocyte telomere attritionen_US
dc.typeArticleen_US
dc.identifier.doihttp://dx.doi.org/10.1210/jc.2016-3035
dcterms.dateAccepted2016-11-22
rioxxterms.funderCardiff Metropolitan Universityen_US
rioxxterms.identifier.projectCardiff Metropolian (Internal)en_US
rioxxterms.versionVoRen_US
rioxxterms.licenseref.urihttp://www.rioxx.net/licenses/all-rights-reserveden_US
rioxxterms.licenseref.startdate2017-01-17
rioxxterms.funder.project37baf166-7129-4cd4-b6a1-507454d1372een_US


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