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dc.contributor.authorMuggeridge, David
dc.contributor.authorSculthorpe, Nicholas
dc.contributor.authorFergal, Grace
dc.contributor.authorWillis, Gareth
dc.contributor.authorThornhill, Laurence
dc.contributor.authorWeller, Richard
dc.contributor.authorJames, Philip
dc.contributor.authorEaston, Chris
dc.date.accessioned2017-01-17T16:10:01Z
dc.date.available2017-01-17T16:10:01Z
dc.date.issued2015-08-01
dc.identifier.citationMuggeridge, D.J, Sculthorpe, N, Grace, F.M, Willis, G, Thornhill, L, Weller, R.B, James, P.E & Easton, C. (2015) 'Acute whole body UVA irradiation combined with nitrate ingestion enhances time trial performance in trained cyclists' Nitric Oxide: Biology and Chemistry, 48 pp.3-9en_US
dc.identifier.issn1089-8603
dc.identifier.urihttp://hdl.handle.net/10369/8305
dc.description.abstractAbstract Dietary nitrate supplementation has been shown to increase nitric oxide (NO) metabolites, reduce blood pressure (BP) and enhance exercise performance. Acute exposure to ultraviolet (UV)-A light also increases NO bioavailability and reduces BP. We conducted a randomized, counterbalanced placebo-controlled trial to determine the effects of UV-A light alone and in combination with nitrate on the responses to sub-maximal steady-state exercise and time trial (TT) performance. Nine cyclists (VO2max 53.1 ± 4.4 ml/kg/min) completed five performance trials comprising 10 min submaximal steady-state cycling followed by a 16.1 km TT. Following a familiarization the final four trials were preceded, in random order, by either (1) Nitrate gels (NIT) + UV-A, (2) Placebo (PLA) + UV-A, (3) NIT + Sham light (SHAM) and (4) PLA + SHAM (control). The NIT gels (2 × 60 ml gels, ~8.1 mmol nitrate) or a low-nitrate PLA were ingested 2.5 h prior to the trial. The light exposure consisted of 20 J/cm2 whole body irradiation with either UV-A or SHAM light. Plasma nitrite was measured pre- and post-irradiation and VO2 was measured continuously during steady-state exercise. Plasma nitrite was higher for NIT + SHAM (geometric mean (95% CI), 332 (292–377) nM; P = 0.029) and NIT + UV-A (456 (312–666) nM; P = 0.014) compared to PLA + SHAM (215 (167–277) nM). Differences between PLA + SHAM and PLA + UV-A (282 (248–356) nM) were small and non-significant. During steady-state exercise VO2 was reduced following NIT + UVA (P = 0.034) and tended to be lower in NIT + SHAM (P = 0.086) but not PLA + UV-A (P = 0.381) compared to PLA + SHAM. Performance in the TT was significantly faster following NIT + UV-A (mean ± SD 1447 ± 41 s P = 0.005; d = 0.47), but not PLA + UV-A (1450 ± 40 s; d = 0.41) or NIT + SHAM (1455 ± 47 s; d = 0.28) compared to PLA + SHAM (1469 ± 52 s). These findings demonstrate that exposure to UV-A light alone does not alter the physiological responses to exercise or improve performance in a laboratory setting. A combination of UV-A and NIT, however, does improve cycling TT performance in this environment, which may be due to a larger increase in NO availabilityen_US
dc.language.isoenen_US
dc.publisherElsevieren_US
dc.relation.ispartofseriesNitric Oxide
dc.subjectExerciseen_US
dc.subjectNitric Oxideen_US
dc.subjectcyclistsen_US
dc.subjectingestionen_US
dc.subjecttime trial performanceen_US
dc.titleAcute whole body UVA irradiation combined with nitrate ingestion enhances time trial performance in trained cyclistsen_US
dc.typeArticleen_US
dc.identifier.doihttp://dx.doi.org/10.1016/j.niox.2014.09.158
dcterms.dateAccepted2015-04-01
rioxxterms.funderCardiff Metropolitan Universityen_US
rioxxterms.identifier.projectCardiff Metropolian (Internal)en_US
rioxxterms.versionAMen_US
rioxxterms.licenseref.urihttp://www.rioxx.net/licenses/all-rights-reserveden_US
rioxxterms.licenseref.startdate2017-01-17
rioxxterms.funder.project37baf166-7129-4cd4-b6a1-507454d1372een_US


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