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dc.contributor.authorDavies, Nia
dc.contributor.authorLlwyd, L
dc.contributor.authorBrugniaux, J.V.
dc.contributor.authorDavies, G.R.
dc.contributor.authorMarley, C.J.
dc.contributor.authorHodson, D
dc.contributor.authorLawrence, M.J.
dc.contributor.authorD'Silva, L.A.
dc.contributor.authorMorris, Keith
dc.contributor.authorWilliams, P.R.
dc.contributor.authorBailey, D.M.
dc.contributor.authorEvans, P.A.
dc.date.accessioned2017-02-01T15:31:15Z
dc.date.available2017-02-01T15:31:15Z
dc.date.issued2016-07
dc.identifier.issn0049-3848
dc.identifier.urihttp://hdl.handle.net/10369/8324
dc.description.abstractBackground Exercise is well established to lead to exercise-induced hypercoagulability, as demonstrated by kinetic coagulation markers. It remains unclear as to whether exercise-induces changes lead in clot development and increased polymerisation. Fractal dimension (df) has been shown to act as a marker of clot microstructure and mechanical properties, and may provide a more meaningful method of determining the relationship between exercise-induced hypercoagulability and potential clot development. Methods df was measured in 24 healthy individuals prior to, after 5 min of submaximal exercise, following maximal exercise, 45 min of passive recovery and following 60 min of recovery. Results were compared with conventional markers of coagulation, fibrinolysis and SEM images. Results Significantly increased df was observed following exercise, returning to resting values following 60 min of recovery. The relationship between df and mature clot microstructure was confirmed by SEM: higher df was associated with dense clots formed of smaller fibrin fibres immediately following exercise compared to at rest. Conventional markers of coagulation confirmed findings of previous studies. Conclusion This study demonstrates that df is a sensitive technique which quantifies the structure and properties of blood clots following exercise. In healthy individuals, the haemostatic balance between coagulation and fibrinolysis is maintained in equilibrium following exercise. In individuals with underlying vascular damage who participate in exercise, this equilibrium may be displaced and lead to enhanced clot formation and a prothrombotic state. df may therefore have the potential to not only quantify hypercoagulability, but may also be useful in screening these individuals.en_US
dc.language.isoenen_US
dc.publisherElsevieren_US
dc.relation.ispartofseriesThrombosis Research;
dc.subjectClot Structureen_US
dc.subjectExerciseen_US
dc.subjectBiomarkeren_US
dc.subjectFractalen_US
dc.titleEffects of exercise intensity on clot microstructure and mechanical properties in healthy individuals.en_US
dc.typeArticleen_US
dc.identifier.doihttp://dx.doi.org/10.1016/j.thromres.2016.05.018
dcterms.dateAccepted2016-05-18
rioxxterms.versionAMen_US
rioxxterms.licenseref.urihttps://creativecommons.org/licenses/by-nc-nd/3.0/en_US
rioxxterms.licenseref.startdate2017-02-01
dc.refexceptionThere was a delay in securing the final peer-reviewed text
rioxxterms.freetoread.startdate2017-05-20


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