Honey is potentially effective in the treatment of atopic dermatitis: Clinical and mechanistic studies

View/ open
Author
Alangari, Abdullah A
Morris, Keith
Lwaleed, Bashir A
Lau, Laurie
Jones, Ken
Cooper, Rose
Jenkins, Rowena
Date
2017-03-30Acceptance date
2017-01-23
Type
Article
Publisher
Wiley
Metadata
Show full item recordAbstract
Introduction: As manuka honey (MH) exhibits immunoregulatory and anti-staphylococcal activities, we aimed to investigate if it could be effective in the treatment of atopic dermatitis (AD).
Methods: Adult volunteers with bilateral AD lesions were asked to apply MH on one site overnight for 7 consecutive days and leave the contralateral site untreated as possible. Three Item Severity score was used to evaluate the response. Skin swabs were obtained from both sites before and after treatment to investigate the presence of staphylococci and enterotoxin production. In addition, the ability of MH and its methanolic and hexane extracts to down regulate IL4-induced CCL26 protein release from HaCaT cells was evaluated by enzyme linked immunosorbent assay. Also, the ability of MH to modulate calcium ionophore-induced mast cell degranulation was assessed by enzyme immunoassay.
Results: In 14 patients, AD lesions significantly improved post MH treatment vs. pre-treatment as compared to control lesions. No significant changes in the skin staphylococci were observed after day 7, irrespective of honey treatment. Consistent with the clinical observation, MH significantly down regulated IL4-induced CCL26 release from HaCaT cells in a dose dependent manner. This effect was partially lost, though remained significant, when methanolic and hexane extracts of MH were utilized. In addition, mast cell degranulation was significantly inhibited following treatment with MH.
Conclusions: MH is potentially effective in the treatment of AD lesions based on both clinical and cellular studies through different mechanisms. This needs to be confirmed by randomized and controlled clinical trials.
Journal/conference proceeding
Immunity, Inflammation and Disease;
Citation
Alangari, A. A., Morris,, K., Lwaleed, B. A., Lau, L., Jones, K., Cooper, R. and Jenkins, R. (2017) 'Honey is potentially effective in the treatment of atopic dermatitis: Clinical and mechanistic studies', Immunity, Inflammation and Disease, 5 (2), pp. 190-199
Description
This article was published Open Access in Immunity, Inflammation and Disease (online) available at http://dx.doi.org/10.1002/iid3.153
Sponsorship
King Saud University (Grant ID: RGP-VPP-190)
Collections
Related items
Showing items related by title, author, subject and abstract.
-
Protective effects of acute exercise prior to doxorubicin on cardiac function of breast cancer patients: A proof-of-concept RCT
Kirkham, Amy; Shave, Rob; Bland, Kelcey; Bovard, Josh; Eves, Neil; Gelmon, Karen; Virani, Sean; Stöhr, Eric J.; Warburton, Darren; Campbell, Kristin (Elsevier, 2017-07-14)Background: Preclinical studies have reported that a single treadmill session performed 24 h prior to doxorubicin provides cardio-protection. We aimed to characterize the acute change in cardiac function following an initial ... -
Cognitive behaviour therapy for bulimia nervosa and eating disorders not otherwise specified: Translation from randomized controlled trial to a clinical setting
Knott, Sarah; Woodward, Debbie; Hoefkens, Antonia; Limbert, Caroline (Cambridge University Press, 2015)Background: Enhanced Cognitive Behaviour Therapy (CBT-E) (Fairburn, Cooper and Shafran, 2003) was developed as a treatment approach for eating disorders focusing on both core psychopathology and additional maintenance ... -
TREATMENT EFFICACY AND ADHERENCE: DOES THE THREE BASIC NEEDS MEDIATE THIS RELATIONSHIP
Amos, Gabrielle (University of Wales Institute Cardiff, 2012)This study examined the relationships between adherence, treatment efficacy and the three basic needs of the Self-determination Theory (SDT). The author looks to find, if the basic needs explains the relationship between ...