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Honey is potentially effective in the treatment of atopic dermatitis: Clinical and mechanistic studies

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Author
Alangari, Abdullah A
Morris, Keith
Lwaleed, Bashir A
Lau, Laurie
Jones, Ken
Cooper, Rose
Jenkins, Rowena
Date
2017-03-30
Acceptance date
2017-01-23
Type
Article
Publisher
Wiley
Metadata
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Abstract
Introduction: As manuka honey (MH) exhibits immunoregulatory and anti-staphylococcal activities, we aimed to investigate if it could be effective in the treatment of atopic dermatitis (AD). Methods: Adult volunteers with bilateral AD lesions were asked to apply MH on one site overnight for 7 consecutive days and leave the contralateral site untreated as possible. Three Item Severity score was used to evaluate the response. Skin swabs were obtained from both sites before and after treatment to investigate the presence of staphylococci and enterotoxin production. In addition, the ability of MH and its methanolic and hexane extracts to down regulate IL4-induced CCL26 protein release from HaCaT cells was evaluated by enzyme linked immunosorbent assay. Also, the ability of MH to modulate calcium ionophore-induced mast cell degranulation was assessed by enzyme immunoassay. Results: In 14 patients, AD lesions significantly improved post MH treatment vs. pre-treatment as compared to control lesions. No significant changes in the skin staphylococci were observed after day 7, irrespective of honey treatment. Consistent with the clinical observation, MH significantly down regulated IL4-induced CCL26 release from HaCaT cells in a dose dependent manner. This effect was partially lost, though remained significant, when methanolic and hexane extracts of MH were utilized. In addition, mast cell degranulation was significantly inhibited following treatment with MH. Conclusions: MH is potentially effective in the treatment of AD lesions based on both clinical and cellular studies through different mechanisms. This needs to be confirmed by randomized and controlled clinical trials.  
Journal/conference proceeding
Immunity, Inflammation and Disease;
Citation
Alangari, A. A., Morris,, K., Lwaleed, B. A., Lau, L., Jones, K., Cooper, R. and Jenkins, R. (2017) 'Honey is potentially effective in the treatment of atopic dermatitis: Clinical and mechanistic studies', Immunity, Inflammation and Disease, 5 (2), pp. 190-199
URI
http://hdl.handle.net/10369/8409
DOI
http://dx.doi.org/10.1002/iid3.153
Description
This article was published Open Access in Immunity, Inflammation and Disease (online) available at http://dx.doi.org/10.1002/iid3.153
Rights
https://creativecommons.org/licenses/by/4.0/
Sponsorship
King Saud University (Grant ID: RGP-VPP-190)
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  • Health and Risk Management [387]

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