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dc.contributor.authorAlangari, Abdullah A
dc.contributor.authorMorris, Keith
dc.contributor.authorLwaleed, Bashir A
dc.contributor.authorLau, Laurie
dc.contributor.authorJones, Ken
dc.contributor.authorCooper, Rose
dc.contributor.authorJenkins, Rowena
dc.date.accessioned2017-03-29T13:52:57Z
dc.date.available2017-03-29T13:52:57Z
dc.date.issued2017-03-30
dc.identifier.citationAlangari, A. A., Morris,, K., Lwaleed, B. A., Lau, L., Jones, K., Cooper, R. and Jenkins, R. (2017) 'Honey is potentially effective in the treatment of atopic dermatitis: Clinical and mechanistic studies', Immunity, Inflammation and Disease, 5 (2), pp. 190-199en_US
dc.identifier.urihttp://hdl.handle.net/10369/8409
dc.descriptionThis article was published Open Access in Immunity, Inflammation and Disease (online) available at http://dx.doi.org/10.1002/iid3.153en_US
dc.description.abstractIntroduction: As manuka honey (MH) exhibits immunoregulatory and anti-staphylococcal activities, we aimed to investigate if it could be effective in the treatment of atopic dermatitis (AD). Methods: Adult volunteers with bilateral AD lesions were asked to apply MH on one site overnight for 7 consecutive days and leave the contralateral site untreated as possible. Three Item Severity score was used to evaluate the response. Skin swabs were obtained from both sites before and after treatment to investigate the presence of staphylococci and enterotoxin production. In addition, the ability of MH and its methanolic and hexane extracts to down regulate IL4-induced CCL26 protein release from HaCaT cells was evaluated by enzyme linked immunosorbent assay. Also, the ability of MH to modulate calcium ionophore-induced mast cell degranulation was assessed by enzyme immunoassay. Results: In 14 patients, AD lesions significantly improved post MH treatment vs. pre-treatment as compared to control lesions. No significant changes in the skin staphylococci were observed after day 7, irrespective of honey treatment. Consistent with the clinical observation, MH significantly down regulated IL4-induced CCL26 release from HaCaT cells in a dose dependent manner. This effect was partially lost, though remained significant, when methanolic and hexane extracts of MH were utilized. In addition, mast cell degranulation was significantly inhibited following treatment with MH. Conclusions: MH is potentially effective in the treatment of AD lesions based on both clinical and cellular studies through different mechanisms. This needs to be confirmed by randomized and controlled clinical trials.  en_US
dc.language.isoenen_US
dc.publisherWileyen_US
dc.relation.ispartofseriesImmunity, Inflammation and Disease;
dc.subjectManuka Honeyen_US
dc.subjectAtopic dermatitisen_US
dc.subjectKeratinocytesen_US
dc.subjectMast Cellsen_US
dc.titleHoney is potentially effective in the treatment of atopic dermatitis: Clinical and mechanistic studiesen_US
dc.typeArticleen_US
dc.identifier.doihttp://dx.doi.org/10.1002/iid3.153
dcterms.dateAccepted2017-01-23
rioxxterms.funderKing Saud University
rioxxterms.identifier.projectRGP-VPP-190
rioxxterms.versionAMen_US
rioxxterms.licenseref.urihttps://creativecommons.org/licenses/by/4.0/en_US
rioxxterms.licenseref.startdate2017-03-29
rioxxterms.funder.project0ab21181-9d2c-41a6-a188-2f7a3bf7fdac


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