• English
    • Welsh
  • English 
    • English
    • Welsh
  • Login
Search DSpace:
  • Home
  • Research at Cardiff Met
  • Library Services
  • Contact Us
View item 
  • DSpace home
  • Cardiff School of Sport and Health Sciences
  • Health and Risk Management
  • View item
  • DSpace home
  • Cardiff School of Sport and Health Sciences
  • Health and Risk Management
  • View item
JavaScript is disabled for your browser. Some features of this site may not work without it.

Foetal Ureaplasma parvum bacteraemia as a function of gestation-dependent complement insufficiency: Evidence from a sheep model of pregnancy

Thumbnail
View/open
Author's post-print (233.8Kb)
Author
Kemp, Matthew W.
Ahmed, Shatha
Beeton, Michael L.
Payne, Matthew S.
Saito, Masatoshi
Miura, Yuichiro
Usuda, Haruo
Kallapur, Suhas G.
Kramer, Boris W.
Stock, Sarah J.
Jobe, Alan H.
Newnham, John P.
Spiller, Owen B.
Date
2016-11-14
Acceptance date
2016-10-13
Type
Article
Publisher
Wiley
ISSN
1600-0897
1046-7408
Metadata
Show full item record
Abstract
Problem Complement is a central defence against sepsis, and increasing complement insufficiency in neonates of greater prematurity may predispose to increased sepsis. Ureaplasma spp. are the most frequently cultured bacteria from preterm blood samples. Method of study A sheep model of intrauterine Ureaplasma parvum infection was used to examine in vivo Ureaplasma bacteraemia at early and late gestational ages. Complement function and Ureaplasma killing assays were used to determine the correlation between complement potency and bactericidal activity of sera ex vivo. Results Ureaplasma was cultured from 50% of 95-day gestation lamb cord blood samples compared to 10% of 125-day gestation lambs. Bactericidal activity increased with increased gestational age, and a direct correlation between functional complement activity and bactericidal activity (R2=.86; P<.001) was found for 95-day gestational lambs. Conclusions Ureaplasma bacteraemia in vivo was confined to early preterm lambs with low complement function, but Ureaplasma infection itself did not diminish complement levels.
Journal/conference proceeding
American Journal of Reproductive Immunology;
Citation
Kemp, M.W., Ahmed, S., Beeton, M.L., Payne, M.S., Saito, M., Miura, Y., Usuda, H., Kallapur, S.G., Kramer, B.W., Stock, S.J., Jobe, A.H., Newnham, J.P., and Spiller, O.B. (2017) 'Foetal Ureaplasma parvum bacteraemia as a function of gestation‐dependent complement insufficiency: Evidence from a sheep model of pregnancy', American Journal of Reproductive Immunology, 77(1).
URI
http://hdl.handle.net/10369/8420
DOI
http://dx.doi.org/10.1111/aji.12599
Description
This article was published in American Journal of Reproductive Immunology on 14 November 2016 (online), available at http://dx.doi.org/10.1111/aji.12599
Rights
Non-Commercialhttp://www.rioxx.net/licenses/all-rights-reserved
Sponsorship
Cardiff Metropolitan University (Grant ID: Cardiff Metropolian (Internal))
Collections
  • Health and Risk Management [392]

Related items

Showing items related by title, author, subject and abstract.

  • Thumbnail

    Isolation of separate Ureaplasma species from endotracheal secretions of twin patients 

    Beeton, Michael L.; Maxwell, Nicola C.; Chalker, Victoria J.; Aboklaish, Ali; Spiller, Owen (American Academy of Pediatrics, 2016-07-14)
    Isolation of Ureaplasma spp. from preterm neonates and the association with development of bronchopulmonary dysplasia has been previously investigated. However, few studies have contrasted the nature of infection in twins. ...
  • Thumbnail

    Protection of the Ovine Fetal Gut against Ureaplasma-Induced Chorioamnionitis: A Potential Role for Plant Sterols 

    van Gorp, Charlotte; de Lange, I.H.; Spiller, O.B.; Dewez, F.; Cillero Pastor, B.; Heeren, R.; Kessels, L.; Kloosterboer, N.; van Gemert, W.L.; Beeton, Michael L.; Stock, S.J. (MDPI, 2019-04-27)
    Chorioamnionitis, clinically most frequently associated with Ureaplasma, is linked to intestinal inflammation and subsequent gut injury. No treatment is available to prevent chorioamnionitis-driven adverse intestinal ...
  • Thumbnail

    Left ventricular mechanics in late second trimester of healthy pregnancy 

    Meah, Victoria L.; Backx, Karianne; Cockcroft, John R.; Shave, Rob; Stöhr, Eric J. (Wiley, 2019-09-04)
    Objective: To evaluate left ventricular (LV) mechanics in the second trimester of healthy pregnancy and to determine the influence of underpinning hemodynamics (heart rate (HR), preload and afterload) on LV mechanics ...

Browse

DSpace at Cardiff MetCommunities & CollectionsBy issue dateAuthorsTitlesSubjectsThis collectionBy issue dateAuthorsTitlesSubjects

My Account

Login

Statistics

Most Popular ItemsStatistics by CountryMost Popular Authors

DSpace software copyright © 2002-2015  DuraSpace
Contact us | Send feedback | Administrator