Show simple item record

dc.contributor.authorBoulet, Lindsey M
dc.contributor.authorLovering, Andrew T
dc.contributor.authorTymko, Michael M
dc.contributor.authorDay, Trevor A
dc.contributor.authorStembridge, Mike
dc.contributor.authorAnh Nguyen, Trang
dc.contributor.authorAinslie, Philip
dc.contributor.authorFoster, Glen E
dc.date.accessioned2017-04-10T08:31:30Z
dc.date.available2017-04-10T08:31:30Z
dc.date.issued2017-03-30
dc.identifier.citationBoulet, L.M., Lovering, A.T., Tymko, M.M., Day, T.A., Stembridge, M., Nguyen, T.A., Ainslie, P.N. and Foster, G.E. (2017) 'Reduced blood flow through intrapulmonary arteriovenous anastomoses during exercise in lowlanders during acclimatization to high altitude', Experimental Physiology, 102 (6), pp. 670–683en_US
dc.identifier.issn0958-0670
dc.identifier.issn1469-445X
dc.identifier.urihttp://hdl.handle.net/10369/8421
dc.descriptionThis article was published in Experimental Physiology on 30 March 2017 (online), available at http://dx.doi.org/10.1113/EP086182en_US
dc.description.abstractBlood flow through intrapulmonary arteriovenous anastomoses (QIPAVA ) is elevated during exercise at sea level (SL) and at rest in acute normobaric hypoxia. Following high altitude (HA) acclimatization, resting QIPAVA is similar to SL, but it is unknown if this is true during exercise at HA. We reasoned that exercise at HA (5,050 m) would exacerbate QIPAVA due to heightened pulmonary arterial pressure. Using a supine cycle ergometer, seven healthy adults free from intracardiac shunts underwent an incremental exercise test at SL (25, 50, 75% of SL VO2peak ) and at HA (25, 50% of SL VO2peak ). Echocardiography was used to determine cardiac output (Q) and pulmonary artery systolic pressure (PASP) and agitated saline contrast was used to determine QIPAVA (bubble score; 0-5). The principal findings were: (1) Q was similar at SL-rest (3.9 +/- 0.47 l min-1 ) compared with HA-rest (4.5 +/- 0.49 l min-1 ; P = 0.382), but increased from rest during both SL and HA exercise (P < 0.001); (2) PASP increased from SL-rest (19.2 +/- 0.7 mmHg) to HA-rest (33.7 +/- 2.8 mmHg; P = 0.001) and, compared with SL, PASP was further elevated during HA exercise (P = 0.003); (3) QIPAVA was increased from SL-rest (0) to HA-rest (median = 1; P = 0.04) and increased from resting values during SL exercise (P < 0.05), but were unchanged during HA exercise (P = 0.91), despite significant increases in Q and PASP. Theoretical modeling of microbubble dissolution suggests that the lack of QIPAVA in response to exercise at HA is unlikely caused by saline contrast instability.en_US
dc.description.sponsorshipGouvernement du Canada | Natural Sciences and Engineering Research Council of Canada (Conseil de Recherches en Sciences Naturelles et en Génie du Canada): Glen E Foster, 2014-05643en_US
dc.language.isoenen_US
dc.publisherWileyen_US
dc.relation.ispartofseriesExperimental Physiology;
dc.rightsNon-Commercial
dc.subjectintrapulmonary arteriovenous anastomosesen_US
dc.subjectexerciseen_US
dc.subjecthigh altitudeen_US
dc.subjectcontrast dissolutionen_US
dc.titleReduced blood flow through intrapulmonary arteriovenous anastomoses at rest and during exercise in lowlanders during acclimatization to high altitudeen_US
dc.typeArticleen_US
dc.identifier.doihttp://dx.doi.org/10.1113/EP086182
dcterms.dateAccepted2017-03-27
rioxxterms.funderCardiff Metropolitan Universityen_US
rioxxterms.identifier.projectCardiff Metropolian (Internal)en_US
rioxxterms.versionAMen_US
rioxxterms.licenseref.urihttp://www.rioxx.net/licenses/under-embargo-all-rights-reserveden_US
rioxxterms.licenseref.startdate2017-04-10
rioxxterms.freetoread.startdate2018-03-30
rioxxterms.funder.project37baf166-7129-4cd4-b6a1-507454d1372een_US


Files in this item

Thumbnail

This item appears in the following collection(s)

Show simple item record