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dc.contributor.authorRoberton, Victoria H.
dc.contributor.authorRosser, Anne E.
dc.contributor.authorKelly, Claire
dc.date.accessioned2017-04-27T08:51:48Z
dc.date.available2017-04-27T08:51:48Z
dc.date.issued2015-05
dc.identifier.citationRoberton, V.H., Rosser, A.E. and Kelly, C.M. (2015) 'Neonatal desensitization for the study of regenerative medicine', Regenerative medicine, 10(3), pp.265-274en_US
dc.identifier.issn1746-0751
dc.identifier.issn1746-076X (ESSN)
dc.identifier.urihttp://hdl.handle.net/10369/8432
dc.descriptionThis article was published in Regenerative Medicine in May 2015 available at http://dx.doi.org/10.2217/rme.14.76en_US
dc.description.abstractCell replacement is a therapeutic option for numerous diseases of the CNS. Current research has identified a number of potential human donor cell types, for which preclinical testing through xenotransplantation in animal models is imperative. Immune modulation is necessary to promote donor cell survival for sufficient time to assess safety and efficacy. Neonatal desensitization can promote survival of human donor cells in adult rat hosts with little impact on the health of the host and for substantially longer than conventional methods, and has subsequently been applied in a range of studies with variable outcomes. Reviewing these findings may provide insight into the method and its potential for use in preclinical studies in regenerative medicine.en_US
dc.language.isoenen_US
dc.publisherFuture Medicineen_US
dc.relation.ispartofseriesRegenerative Medicine;
dc.subjectTransplantationen_US
dc.subjectrodent modelsen_US
dc.subjectcell replacementen_US
dc.subjectHuntington’s diseaseen_US
dc.subjectimmunosuppressionen_US
dc.subjectxenograften_US
dc.subjectdesensitisationen_US
dc.subjectrejectionen_US
dc.titleNeonatal desensitisation for the study of regenerative medicineen_US
dc.typeArticleen_US
dc.identifier.doihttp://dx.doi.org/10.2217/rme.14.76
dcterms.dateAccepted2015
rioxxterms.funderCardiff Metropolitan Universityen_US
rioxxterms.identifier.projectCardiff Metropolian (Internal)en_US
rioxxterms.versionAMen_US
rioxxterms.licenseref.urihttp://www.rioxx.net/licenses/all-rights-reserveden_US
rioxxterms.licenseref.startdate2017-04-27
rioxxterms.funder.project37baf166-7129-4cd4-b6a1-507454d1372een_US


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