Differential impact of water immersion on arterial blood flow and shear stress in the carotid and brachial arteries of humans
Pugh, Christopher J. A.
Wiley Periodicals, Inc.
MetadataShow full item record
Arterial shear stress is a potent stimulus to vascular adaptation in humans. Typically, increases in retrograde shear have been found to acutely impair vascular function while increases in antegrade shear enhance function. We hypothesized that blood flow and shear stress through the brachial and carotid arteries would change in a similar manner in response to water immersion, an intervention which modifies hemodynamics. Nine healthy young male subjects were recruited to undergo controlled water immersion in a standing upright position to the level of the right atrium in 30°C water. Diameters were continuously and simultaneously recorded in the brachial and common carotid arteries along with mean arterial pressure (MAP), cardiac output (CO), and heart rate before, during, and after 10 min of immersion. MAP and CO increased during water immersion (baseline vs. 8–10 min; 80 9 vs. 91 12 mmHg; and 4.8 0.7 vs. 5.1 0.6 L/min, P < 0.01 and P < 0.05, respectively). We observed a differential regulation of flow and shear stress patterns in the brachial and carotid arteries in response to water immersion; brachial conductance decreased markedly in response to immersion (1.25 0.56 vs. 0.57 0.30 mL.min/mmHg, P < 0.05), whereas it was unaltered in the carotid artery (5.82 2.14 vs. 5.60 1.59). Our findings indicate that adaptations to systemic stimuli and arterial adaptation may be vessel bed specific in humans, highlighting the need to assess multiple vascular sites in future studies.
Carter, H.H., Spence, A.L., Ainslie, P.N., Pugh, C.J., Naylor, L.H. and Green, D.J. (2017) 'Differential impact of water immersion on arterial blood flow and shear stress in the carotid and brachial arteries of humans', Physiological Reports, 5(10), p.e13285.
This article was published in Physiological Reports on 30 May 2017, available open access at http://dx.doi.org/10.14814/phy2.13285
Cardiff Metropolitan University (Grant ID: Cardiff Metropolian (Internal))
- Sport Research Groups 
Showing items related by title, author, subject and abstract.
Dawson, Ellen; Whyte, Greg; Black, Mark; Jones, Helen; Hopkins, Nicola; Oxborough, David; Gaze, David; Shave, Rob; Wilson, Matthew; George, Keith; Green, Daniel J. (American Physiological Society, 2008)Prolonged exercise has been shown to result in an acute depression in cardiac function. However, little is known about the effect of this type of exercise on vascular function. Therefore, the purpose of the present study ...
Interaction between left ventricular twist mechanics and arterial haemodynamics during localised, non-metabolic hyperaemia with and without blood flow restriction van Mil, Anke C.C.M.; Pearson, James; Drane, Aimee L.; McDonnell, Barry; Stöhr, Eric J. (Wiley, 2016)Whether left ventricular twist and untwisting rate (LV twist mechanics) respond to localised, peripheral, non-metabolic changes in arterial haemodynamics within an individual’s normal afterload-range is presently unknown. ...
The effect of alpha1-adrenergic blockade on post-exercise brachial artery flow-mediated dilatation at sea-level and high-altitude Tymko, Michael; Tremblay, Joshua; Howe, Connor; Willie, Christopher; Stembridge, Mike; Green, Daniel; Hoiland, Ryan; Subedi, Prajan; Anholm, James; Ainslie, Philip (Wiley, 2016-11-07)We examined the hypotheses that 1) at rest, endothelial function would be impaired at high- altitude compared to sea-level, 2) endothelial function would be reduced to a greater extent at sea-level compared to high-altitude ...