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One session of remote ischemic preconditioning does not improve vascular function in acute normobaric and chronic hypobaric hypoxia

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Author
Rieger, Mathew
Tremblay, Joshua
Stembridge, Mike
Bain, Anthony
Fluck, Daniela
Subedi, Prajan
Anholm, James
Ainslie, Philip
Date
2017-07-12
Acceptance date
2017-06-30
Type
Article
Publisher
Wiley
ISSN
0958-0670
1469-445X (ESSN)
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Abstract
Application of repeated short duration bouts of ischemia to the limbs, termed remote ischemic preconditioning (RIPC), is a novel technique that may have protective effects on vascular function during hypoxic exposures. In separate parallel-design studies, at sea-level (SL; n=16), and after 8-12 days at high-altitude (HA; n=12; White Mountain, 3800m), participants underwent either a sham protocol or one session of 4x5 minutes of dual-thigh cuff occlusion with 5-minutes recovery. Brachial artery flow-mediated dilation (FMD; ultrasound), pulmonary artery systolic pressure (PASP; echocardiography), and internal carotid artery flow (ICA; ultrasound) were measured at SL in normoxia and isocapnic hypoxia [end-tidal PO (PETO ) maintained to 50mmHg], and during normal breathing at HA. The hypoxic ventilatory response (HVR) was measured at each location. All measures at SL and HA were obtained at baseline (BL), 1 hour, 24 hours, and 48 hours post-RIPC or sham. At SL, RIPC produced no changes in FMD, PASP, ICA flow, end-tidal gases or HVR in normoxia or hypoxia. At HA, although HVR increased 24 hours post RIPC compared to BL (2.05{plus minus}1.4 vs. 3.21{plus minus}1.2 L•min-1•%SaO2-1, p<0.01), there were no significant differences in FMD, PASP, ICA flow, resting end-tidal gases. Accordingly, a single session of RIPC is insufficient to evoke changes in peripheral, pulmonary, and cerebral vascular function in healthy adults. Although chemosensitivity may increase following RIPC at HA, this did not confer any vascular changes. The utility of a single RIPC session seems unremarkable during acute and chronic hypoxia.
Journal/conference proceeding
Experimental Physiology;
Citation
Rieger, M. G., Hoiland, R. L., Tremblay, J. C., Stembridge, M., Bain, A. R., Flück, D., Subedi, P., Anholm, J. D. and Ainslie, P. N. (2017), 'One session of remote ischemic preconditioning does not improve vascular function in acute normobaric and chronic hypobaric hypoxia', Experimental Physiology
URI
http://hdl.handle.net/10369/8672
DOI
http://dx.doi.org/10.1113/EP086441
Description
This article was published in Journal of Applied Microbiology on 12 July 2017 (online), available at http://dx.doi.org/10.1113/EP086441
Rights
http://www.rioxx.net/licenses/all-rights-reserved
Sponsorship
Cardiff Metropolitan University (Grant ID: Cardiff Metropolian (Internal))
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