Show simple item record

dc.contributor.authorRieger, Mathew
dc.contributor.authorTremblay, Joshua
dc.contributor.authorStembridge, Mike
dc.contributor.authorBain, Anthony
dc.contributor.authorFluck, Daniela
dc.contributor.authorSubedi, Prajan
dc.contributor.authorAnholm, James
dc.contributor.authorAinslie, Philip
dc.date.accessioned2017-07-31T11:49:33Z
dc.date.available2017-07-31T11:49:33Z
dc.date.issued2017-07-12
dc.identifier.citationRieger, M. G., Hoiland, R. L., Tremblay, J. C., Stembridge, M., Bain, A. R., Flück, D., Subedi, P., Anholm, J. D. and Ainslie, P. N. (2017), 'One session of remote ischemic preconditioning does not improve vascular function in acute normobaric and chronic hypobaric hypoxia', Experimental Physiologyen_US
dc.identifier.issn0958-0670
dc.identifier.issn1469-445X (ESSN)
dc.identifier.urihttp://hdl.handle.net/10369/8672
dc.descriptionThis article was published in Journal of Applied Microbiology on 12 July 2017 (online), available at http://dx.doi.org/10.1113/EP086441en_US
dc.description.abstractApplication of repeated short duration bouts of ischemia to the limbs, termed remote ischemic preconditioning (RIPC), is a novel technique that may have protective effects on vascular function during hypoxic exposures. In separate parallel-design studies, at sea-level (SL; n=16), and after 8-12 days at high-altitude (HA; n=12; White Mountain, 3800m), participants underwent either a sham protocol or one session of 4x5 minutes of dual-thigh cuff occlusion with 5-minutes recovery. Brachial artery flow-mediated dilation (FMD; ultrasound), pulmonary artery systolic pressure (PASP; echocardiography), and internal carotid artery flow (ICA; ultrasound) were measured at SL in normoxia and isocapnic hypoxia [end-tidal PO (PETO ) maintained to 50mmHg], and during normal breathing at HA. The hypoxic ventilatory response (HVR) was measured at each location. All measures at SL and HA were obtained at baseline (BL), 1 hour, 24 hours, and 48 hours post-RIPC or sham. At SL, RIPC produced no changes in FMD, PASP, ICA flow, end-tidal gases or HVR in normoxia or hypoxia. At HA, although HVR increased 24 hours post RIPC compared to BL (2.05{plus minus}1.4 vs. 3.21{plus minus}1.2 L•min-1•%SaO2-1, p<0.01), there were no significant differences in FMD, PASP, ICA flow, resting end-tidal gases. Accordingly, a single session of RIPC is insufficient to evoke changes in peripheral, pulmonary, and cerebral vascular function in healthy adults. Although chemosensitivity may increase following RIPC at HA, this did not confer any vascular changes. The utility of a single RIPC session seems unremarkable during acute and chronic hypoxia.en_US
dc.language.isoenen_US
dc.publisherWileyen_US
dc.relation.ispartofseriesExperimental Physiology;
dc.subjectRemote ischemic preconditioning; High-altitude; Hypoxia; Pulmonary artery pressure; Vascular function; Cerebral blood flow; Chemosensitivityen_US
dc.titleOne session of remote ischemic preconditioning does not improve vascular function in acute normobaric and chronic hypobaric hypoxiaen_US
dc.typeArticleen_US
dc.identifier.doihttp://dx.doi.org/10.1113/EP086441
dcterms.dateAccepted2017-06-30
rioxxterms.funderCardiff Metropolitan Universityen_US
rioxxterms.identifier.projectCardiff Metropolian (Internal)en_US
rioxxterms.versionAMen_US
rioxxterms.licenseref.urihttp://www.rioxx.net/licenses/all-rights-reserveden_US
rioxxterms.licenseref.startdate2017-07-30
rioxxterms.freetoread.startdate2018-07-12
rioxxterms.funder.project37baf166-7129-4cd4-b6a1-507454d1372een_US


Files in this item

Thumbnail

This item appears in the following collection(s)

Show simple item record