Short-term rhGH increases PIIINP, a biomarker of endothelial dysfunction
Graham, M. R
Evans, P. J.
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Objectives: In arterial hypertension, amino-terminal propeptide of type III procollagen (PIIINP) is elevated in arterial aneurysm tissue and associated with a poor prognosis following acute myocardial infarction (MI). Recombinant human growth hormone (rhGH) administration attenuates endothelial dysfunction but increases PIIINP. This study was conducted to establish if short-term rhGH administration affects PIIINP, endothelial function and selected cardiovascular disease (CVD) risk factors, in healthy males. Design: Method: Male subjects (n=48) were randomly assigned into two groups: (1): control group (C) n=24, mean Â± SD, age 32 Â± 11 years; height 1.8 Â± 0.06 metres; (2): rhGH administration group (rhGH) n=24, mean Â± SD, age 32 Â± 9 years; height 1.8 Â± 0.07 metres. Blood pressure (BP), heart rate (HR), arterial pulse wave velocity (APWV), and biochemical indices were investigated. Results: PIIINP (0.28Â±0.1 vs. 0.42Â±0.2, U/ml); Insulin like growth factor-I (159Â±54 vs. 323Â±93, ng.mL-1); resting HR (72Â±14 vs. 78Â±11, b.p.m.) and rate pressure product (RPP) (90Â±18 vs. 97Â±14, bpm x mm.Hg x 10-2) all significantly increased (P<0.05). Total cholesterol (4.7Â±0.9 vs. 4.4Â±0.7, mmol.L-1); high sensitivity C-reactive protein (1.77Â±2.1 vs. 1.29Â±1.6, mg.L-1); serum homocysteine (13.2Â±4.0 vs. 11.7Â±3.1, Î¼mol.L-1) and APWV (9.97Â±1.38 vs. 9.18Â±1.6, m.s-1) all significantly decreased (P<0.05). Conclusion: Paradoxically, there was an improvement in CVD inflammatory markers and APWV; but PIIINP and resting RPP increased. Elevated PIIINP may have a confounding adverse effect on the endothelium, but may also provide clinical prognostic information in monitoring arterial hypertension, left ventricular function in the sub-acute phase following MI and endothelial function in aortic aneurysms.
International Journal of Advanced Engineering Research and Science;
Graham M. R., Gu Y., Evans P. J., Cooper S. M., Davies B. and Baker J. S. (2017) 'Short-term rhGH increases PIIINP, a biomarker of endothelial dysfunction', International Journal of Advanced Engineering Research and Science, 4(7), pp.164-173
This article was published open access in International Journal of Advanced Engineering Research and Science on 01 July 2017, available at http://dx.doi.org/10.22161/ijaers.4.7.26
Cardiff Metropolitan University (Grant ID: Cardiff Metropolian (Internal))
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