Short-term rhGH increases PIIINP, a biomarker of endothelial dysfunction
Graham, M. R
Evans, P. J.
MetadataDangos cofnod eitem llawn
Objectives: In arterial hypertension, amino-terminal propeptide of type III procollagen (PIIINP) is elevated in arterial aneurysm tissue and associated with a poor prognosis following acute myocardial infarction (MI). Recombinant human growth hormone (rhGH) administration attenuates endothelial dysfunction but increases PIIINP. This study was conducted to establish if short-term rhGH administration affects PIIINP, endothelial function and selected cardiovascular disease (CVD) risk factors, in healthy males. Design: Method: Male subjects (n=48) were randomly assigned into two groups: (1): control group (C) n=24, mean Â± SD, age 32 Â± 11 years; height 1.8 Â± 0.06 metres; (2): rhGH administration group (rhGH) n=24, mean Â± SD, age 32 Â± 9 years; height 1.8 Â± 0.07 metres. Blood pressure (BP), heart rate (HR), arterial pulse wave velocity (APWV), and biochemical indices were investigated. Results: PIIINP (0.28Â±0.1 vs. 0.42Â±0.2, U/ml); Insulin like growth factor-I (159Â±54 vs. 323Â±93, ng.mL-1); resting HR (72Â±14 vs. 78Â±11, b.p.m.) and rate pressure product (RPP) (90Â±18 vs. 97Â±14, bpm x mm.Hg x 10-2) all significantly increased (P<0.05). Total cholesterol (4.7Â±0.9 vs. 4.4Â±0.7, mmol.L-1); high sensitivity C-reactive protein (1.77Â±2.1 vs. 1.29Â±1.6, mg.L-1); serum homocysteine (13.2Â±4.0 vs. 11.7Â±3.1, Î¼mol.L-1) and APWV (9.97Â±1.38 vs. 9.18Â±1.6, m.s-1) all significantly decreased (P<0.05). Conclusion: Paradoxically, there was an improvement in CVD inflammatory markers and APWV; but PIIINP and resting RPP increased. Elevated PIIINP may have a confounding adverse effect on the endothelium, but may also provide clinical prognostic information in monitoring arterial hypertension, left ventricular function in the sub-acute phase following MI and endothelial function in aortic aneurysms.
International Journal of Advanced Engineering Research and Science;
Graham M. R., Gu Y., Evans P. J., Cooper S. M., Davies B. and Baker J. S. (2017) 'Short-term rhGH increases PIIINP, a biomarker of endothelial dysfunction', International Journal of Advanced Engineering Research and Science, 4(7), pp.164-173
Dynodwr Gwrthrych Digidol (DOI)http://dx.doi.org/10.22161/ijaers.4.7.26
This article was published open access in International Journal of Advanced Engineering Research and Science on 01 July 2017, available at http://dx.doi.org/10.22161/ijaers.4.7.26
Cardiff Metropolitan University (Grant ID: Cardiff Metropolian (Internal))
- Sport Research Groups 
Yn dangos eitemau sy’n perthyn drwy deitl, awdur, pwnc a chrynodeb.
Swampillai, J.; Rakebrandt, F.; Morris, Keith; Jones, C.; Fraser, A.G. (Wiley-Blackwell Publishing Ltd., 2006)Background Caffeine and tobacco consumption are risk factors for heart failure, but their effects remain controversial. It has been hypothesized that they cause alterations in arterial stiffness and arterial wave travel ...
The relationship between alcohol consumption and arterial stiffness within a young male population Waters, David (Cardiff Metropolitan University, 2014)Aim: Moderate alcohol consumption has been suggested to protect against heart disease. Heavy drinking, and binge drinking has been considered to have a detrimental effect upon cardiovascular health. Arterial stiffness ...
Black, Jane M. (2018)Resistance training is rarely prescribed to enhance cardiovascular function; in fact, suggestions have been made that long-term resistance training may lead to chronic augmentations in carotid arterial stiffness and ...