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dc.contributor.authorGraham, M. R
dc.contributor.authorGu, Y
dc.contributor.authorEvans, P. J.
dc.contributor.authorCooper, Stephen-Mark
dc.contributor.authorDavies, B
dc.contributor.authorBaker, J.S.
dc.date.accessioned2017-08-07T09:35:27Z
dc.date.available2017-08-07T09:35:27Z
dc.date.issued2017-07-01
dc.identifier.citationGraham M. R., Gu Y., Evans P. J., Cooper S. M., Davies B. and Baker J. S. (2017) 'Short-term rhGH increases PIIINP, a biomarker of endothelial dysfunction', International Journal of Advanced Engineering Research and Science, 4(7), pp.164-173en_US
dc.identifier.issn2456-1908 (ESSN)
dc.identifier.urihttp://hdl.handle.net/10369/8680
dc.descriptionThis article was published open access in International Journal of Advanced Engineering Research and Science on 01 July 2017, available at http://dx.doi.org/10.22161/ijaers.4.7.26en_US
dc.description.abstractObjectives: In arterial hypertension, amino-terminal propeptide of type III procollagen (PIIINP) is elevated in arterial aneurysm tissue and associated with a poor prognosis following acute myocardial infarction (MI). Recombinant human growth hormone (rhGH) administration attenuates endothelial dysfunction but increases PIIINP. This study was conducted to establish if short-term rhGH administration affects PIIINP, endothelial function and selected cardiovascular disease (CVD) risk factors, in healthy males. Design: Method: Male subjects (n=48) were randomly assigned into two groups: (1): control group (C) n=24, mean ± SD, age 32 ± 11 years; height 1.8 ± 0.06 metres; (2): rhGH administration group (rhGH) n=24, mean ± SD, age 32 ± 9 years; height 1.8 ± 0.07 metres. Blood pressure (BP), heart rate (HR), arterial pulse wave velocity (APWV), and biochemical indices were investigated. Results: PIIINP (0.28±0.1 vs. 0.42±0.2, U/ml); Insulin like growth factor-I (159±54 vs. 323±93, ng.mL-1); resting HR (72±14 vs. 78±11, b.p.m.) and rate pressure product (RPP) (90±18 vs. 97±14, bpm x mm.Hg x 10-2) all significantly increased (P<0.05). Total cholesterol (4.7±0.9 vs. 4.4±0.7, mmol.L-1); high sensitivity C-reactive protein (1.77±2.1 vs. 1.29±1.6, mg.L-1); serum homocysteine (13.2±4.0 vs. 11.7±3.1, μmol.L-1) and APWV (9.97±1.38 vs. 9.18±1.6, m.s-1) all significantly decreased (P<0.05). Conclusion: Paradoxically, there was an improvement in CVD inflammatory markers and APWV; but PIIINP and resting RPP increased. Elevated PIIINP may have a confounding adverse effect on the endothelium, but may also provide clinical prognostic information in monitoring arterial hypertension, left ventricular function in the sub-acute phase following MI and endothelial function in aortic aneurysms.en_US
dc.language.isoenen_US
dc.publisherAI Publicationsen_US
dc.relation.ispartofseriesInternational Journal of Advanced Engineering Research and Science;
dc.subjectarterial hypertensionen_US
dc.subjectacute myocardial infarctionen_US
dc.subjectcardiovascular disease (CVD)en_US
dc.subjecthealthy malesen_US
dc.titleShort-term rhGH increases PIIINP, a biomarker of endothelial dysfunctionen_US
dc.typeArticleen_US
dc.identifier.doihttp://dx.doi.org/10.22161/ijaers.4.7.26
dcterms.dateAccepted2017-06-15
rioxxterms.funderCardiff Metropolitan Universityen_US
rioxxterms.identifier.projectCardiff Metropolian (Internal)en_US
rioxxterms.versionVoRen_US
rioxxterms.licenseref.urihttps://creativecommons.org/licenses/by-sa/4.0/en_US
rioxxterms.licenseref.startdate2017-08-07
rioxxterms.funder.project37baf166-7129-4cd4-b6a1-507454d1372een_US


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