Age-related differences in left ventricular structure and function between healthy men and women
Stöhr, Eric J.
Taylor and Francis
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Full Article Figures & data References Supplemental Citations Metrics Reprints & Permissions Get access Abstract Objectives: Cardiovascular function generally decreases with age, but whether this decrease differs between men and women is unclear. Our aims were twofold: (1) to investigate age-related sex differences in left ventricular (LV) structure, function and mechanics, and (2) to compare these measures between pre- and postmenopausal women in the middle-aged group. Methods: Resting echocardiography was performed in a cross-sectional sample of 82 healthy adults (14 young men, 19 middle-aged men, 15 young women, 34 middle-aged women: 15 premenopausal and 19 postmenopausal). Two-way ANOVAs were used to examine sex × age interactions, and t-tests to compare pre- and postmenopausal women (α < 0.1). Results: Normalized LV mass, stroke volume and end-diastolic volume were significantly lower in middle-aged than young men, but this difference was smaller between middle-aged and young women. Peak systolic apical mechanics were significantly greater in middle-aged men than in middle-aged women, but not between young men and women. Postmenopausal women had significantly lower LV relaxation and mechanics (torsion, twisting velocity and apical circumferential strain rates) compared with middle-aged premenopausal women. Conclusion: Our cross-sectional findings suggest that the hearts of men and women may age differently, with men displaying greater differences in LV volumes accompanied by differences in apical mechanics.
Nio, A.Q.X., Stohr, E.J. and Shave, R.E. (2017) 'Age-related differences in left ventricular structure and function between healthy men and women', Climacteric, pp. 1-8
This article was published in Climacteric on 08 August 2017, available at http://dx.doi.org/10.1080/13697137.2017.1356814
Cardiff Metropolitan University (Grant ID: Cardiff Metropolian (Internal))
AXA Research Fund
- Sport Research Groups 
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