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dc.contributor.authorNio, Amanda
dc.contributor.authorStöhr, Eric J.
dc.contributor.authorShave, Rob
dc.date.accessioned2017-08-10T09:41:57Z
dc.date.available2017-08-10T09:41:57Z
dc.date.issued2017-08-08
dc.identifier.citationNio, A.Q.X., Stohr, E.J. and Shave, R.E. (2017) 'Age-related differences in left ventricular structure and function between healthy men and women', Climacteric, pp. 1-8en_US
dc.identifier.issn1473-0804 (ESSN)
dc.identifier.urihttp://hdl.handle.net/10369/8694
dc.descriptionThis article was published in Climacteric on 08 August 2017, available at http://dx.doi.org/10.1080/13697137.2017.1356814en_US
dc.description.abstractFull Article Figures & data References Supplemental Citations Metrics Reprints & Permissions Get access Abstract Objectives: Cardiovascular function generally decreases with age, but whether this decrease differs between men and women is unclear. Our aims were twofold: (1) to investigate age-related sex differences in left ventricular (LV) structure, function and mechanics, and (2) to compare these measures between pre- and postmenopausal women in the middle-aged group. Methods: Resting echocardiography was performed in a cross-sectional sample of 82 healthy adults (14 young men, 19 middle-aged men, 15 young women, 34 middle-aged women: 15 premenopausal and 19 postmenopausal). Two-way ANOVAs were used to examine sex × age interactions, and t-tests to compare pre- and postmenopausal women (α < 0.1). Results: Normalized LV mass, stroke volume and end-diastolic volume were significantly lower in middle-aged than young men, but this difference was smaller between middle-aged and young women. Peak systolic apical mechanics were significantly greater in middle-aged men than in middle-aged women, but not between young men and women. Postmenopausal women had significantly lower LV relaxation and mechanics (torsion, twisting velocity and apical circumferential strain rates) compared with middle-aged premenopausal women. Conclusion: Our cross-sectional findings suggest that the hearts of men and women may age differently, with men displaying greater differences in LV volumes accompanied by differences in apical mechanics.en_US
dc.description.sponsorshipAXA Research Fund
dc.language.isoenen_US
dc.publisherTaylor and Francisen_US
dc.relation.ispartofseriesClimacteric;
dc.subjectsex differencesen_US
dc.subjectagingen_US
dc.subjectmenopauseen_US
dc.subjectcardiac functionen_US
dc.subjectleft ventricular mechanicsen_US
dc.titleAge-related differences in left ventricular structure and function between healthy men and womenen_US
dc.typeArticleen_US
dc.identifier.doihttp://dx.doi.org/10.1080/13697137.2017.1356814
dcterms.dateAccepted2017-07-12
rioxxterms.funderCardiff Metropolitan Universityen_US
rioxxterms.identifier.projectCardiff Metropolian (Internal)en_US
rioxxterms.versionAMen_US
rioxxterms.licenseref.urihttps://creativecommons.org/licenses/by-nc-nd/4.0/en_US
rioxxterms.licenseref.startdate2017-08-10
rioxxterms.freetoread.startdate2018-08-08
rioxxterms.funder.project37baf166-7129-4cd4-b6a1-507454d1372een_US


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