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dc.contributor.authorEnnis, Stuart
dc.contributor.authorMcGregor, Gordon
dc.contributor.authorHamborg, Thomas
dc.contributor.authorJones, Helen
dc.contributor.authorShave, Rob
dc.contributor.authorSingh, Sally
dc.contributor.authorBanerjee, Prithwish
dc.date.accessioned2017-08-22T14:16:13Z
dc.date.available2017-08-22T14:16:13Z
dc.date.issued2017-08-11
dc.identifier.citationEnnis S., McGregor G., Hamborg T., Jones, H., Shave, R., Singh, S. and Banerjee, P. (2017) 'Randomised feasibility trial into the effects of low-frequency electrical muscle stimulation in advanced heart failure patients' BMJ Open 7:e016148en_US
dc.identifier.issn2044-6055 (ESSN)
dc.identifier.urihttp://hdl.handle.net/10369/8749
dc.descriptionThis article was published open access in BMJ Open on 11 August 2017 (online), available at http://dx.doi.org/10.1080/17511321.2017.1351484en_US
dc.description.abstractObjectives Low-frequency electrical muscle stimulation (LF-EMS) may have the potential to reduce breathlessness and increase exercise capacity in the chronic heart failure population who struggle to adhere to conventional exercise. The study’s aim was to establish if a randomised controlled trial of LF-EMS was feasible. Design and setting Double blind (participants, outcome assessors), randomised study in a secondary care outpatient cardiac rehabilitation programme. Participants Patients with severe heart failure (New York Heart Association class III–IV) having left ventricular ejection fraction <40% documented by echocardiography were eligible. Interventions Participants were randomised (remotely by computer) to 8 weeks (5×60 mins per week) of either LF-EMS intervention (4 Hz, continuous, n=30) or sham placebo (skin level stimulation only, n=30) of the quadriceps and hamstrings muscles. Participants used the LF-EMS straps at home and were supervised weekly Outcome measures Recruitment, adherence and tolerability to the intervention were measured during the trial as well as physiological outcomes (primary outcome: 6 min walk, secondary outcomes: quadriceps strength, quality of life and physical activity). Results Sixty of 171 eligible participants (35.08%) were recruited to the trial. 12 (20%) of the 60 patients (4 LF-EMS and 8 sham) withdrew. Forty-one patients (68.3%), adhered to the protocol for at least 70% of the sessions. The physiological measures indicated no significant differences between groups in 6 min walk distance(p=0.13) and quality of life (p=0.55) although both outcomes improved more with LF-EMS. Conclusion Patients with severe heart failure can be recruited to and tolerate LF-EMS studies. A larger randomised controlled trial (RCT) in the advanced heart failure population is technically feasible, although adherence to follow-up would be challenging. The preliminary improvements in exercise capacity and quality of life were minimal and this should be considered if planning a larger trial. Trial registration number ISRCTN16749049en_US
dc.language.isoenen_US
dc.publisherBMJ Openen_US
dc.relation.ispartofseriesBMJ Open
dc.subjectheart failureen_US
dc.subjectmuscle stimulationen_US
dc.subjectlow-frequency stimulationen_US
dc.subjectrandomised trialen_US
dc.titleRandomised feasibility trial into the effects of low-frequency electrical muscle stimulation in advanced heart failure patientsen_US
dc.typeArticleen_US
dc.identifier.doihttp://dx.doi.org/10.1136/bmjopen-2017-016148
dcterms.dateAccepted2017-07-07
rioxxterms.funderCardiff Metropolitan Universityen_US
rioxxterms.identifier.projectCardiff Metropolian (Internal)en_US
rioxxterms.versionVoRen_US
rioxxterms.licenseref.urihttp://creativecommons.org/licenses/by/4.0/en_US
rioxxterms.licenseref.startdate2017-08-22
rioxxterms.funder.project37baf166-7129-4cd4-b6a1-507454d1372een_US


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