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dc.contributor.authorStembridge, Mike
dc.contributor.authorHoiland, Ryan
dc.contributor.authorBain, Anthony
dc.contributor.authorBarak, Otto
dc.contributor.authorDrvis, Ivan
dc.contributor.authorMacLeod, David
dc.contributor.authorMacLeod, Douglas
dc.contributor.authorMadden, Dennis
dc.contributor.authorBatinic, Tonci
dc.contributor.authorO'Donoghue, Peter
dc.contributor.authorShave, Rob
dc.contributor.authorDujic, Zeljko
dc.contributor.authorAinslie, Philip N.
dc.date.accessioned2017-08-23T13:24:32Z
dc.date.available2017-08-23T13:24:32Z
dc.date.issued2017-08-01
dc.identifier.citationStembridge, M., Hoiland, R. L., Bain, A. R., Barak, O. F., Drvis, I., MacLeod, D. B., MacLeod, D. M., Madden, D., Batinic, T., O'Donoghue, P., Shave, R., Dujic, Z. and Ainslie, P. N. (2017) 'Influence of lung volume on the interaction between cardiac output and cerebrovascular regulation during extreme apnoea', Experimental Physiology, (in press)en_US
dc.identifier.issn0958-0670
dc.identifier.issn1469-445X (ESSN)
dc.identifier.urihttp://hdl.handle.net/10369/8754
dc.descriptionThis article was published in Experimental Physiology on 01 August 2017, available at http://dx.doi.org/10.1113/EP086429en_US
dc.description.abstractWe investigated the role of lung volume-induced changes in cardiac output (Q ) on cerebrovascular regulation during prolonged apnoea. Fifteen elite apnoea divers (1F; 185 ± 7 cm, 82 ± 12 kg, 29 ± 7 years) attended the laboratory on two separate occasions and completed maximal breath-holds at total lung capacity (TLC) and functional residual capacity (FRC) to elicit disparate cardiovascular responses. Mean arterial pressure (MAP), internal jugular venous pressure (IJVP) and arterial blood gases were measured via cannulation, global cerebral blood flow (gCBF) was quantified by ultrasound and cardiac output via photoplethysmography. At FRC, stroke volume (SV) and cardiac output (Q ) did not change from baseline (P>0.05). In contrast, during the TLC trial SV and Q were decreased until 80% and 40% of apnoea, respectively (P<0.05). During the TLC trial, gCBF was significantly lower at 20%, but subsequently increased so that cerebral oxygen delivery was comparable to the FRC trial. IJVP was significantly higher throughout the TLC trial in comparison to FRC. MAP rose progressively in both trials but to a greater extent at TLC resulting in a comparable cerebral perfusion pressure between trials by apnoea end. In summary, although lung volume has a profound effect on Q during prolonged breath-holding, these changes do not translate to the cerebrovasculature due to the greater sensitivity of CBF to arterial blood gases and MAP; regulatory mechanisms that facilitate the maintenance of cerebral oxygen delivery.en_US
dc.description.sponsorshipDrs. Dujic, Barak, and Ainslie, Philip were funded through the Croatian Science Foundation (grant no. IP-2014-09-1937).en_US
dc.language.isoenen_US
dc.publisherWileyen_US
dc.relation.ispartofseriesExperimental Physiology;
dc.subjectApnoea; diving; cerebral blood flow; cerebral perfusion pressureen_US
dc.titleInfluence of lung volume on the interaction between cardiac output and cerebrovascular regulation during extreme apnoeaen_US
dc.typeJournalen_US
dc.identifier.doihttp://dx.doi.org/10.1113/EP086429
dcterms.dateAccepted2017-07-20
rioxxterms.versionAMen_US
rioxxterms.freetoread.startdate2018-08-01


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