Show simple item record

dc.contributor.authorKirkham, Amy
dc.contributor.authorShave, Rob
dc.contributor.authorBland, Kelcey
dc.contributor.authorBovard, Josh
dc.contributor.authorEves, Neil
dc.contributor.authorGelmon, Karen
dc.contributor.authorVirani, Sean
dc.contributor.authorStöhr, Eric J.
dc.contributor.authorWarburton, Darren
dc.contributor.authorCampbell, Kristin
dc.date.accessioned2017-08-23T14:16:50Z
dc.date.available2017-08-23T14:16:50Z
dc.date.issued2017-07-14
dc.identifierhttps://repository.cardiffmet.ac.uk/bitstream/id/27099/Protective%20effects%20of%20acute%20exercise%20prior%20to%20doxorubicin%20on%20cardiac%20function%20of%20breast%20cancer%20patients%20-%20A%20proof-of-concept%20RCT.pdf
dc.identifier.citationKirkham, A. A., Shave, R. E., Bland, K. A., Bovard, J. M., Eves, N. D., Gelmon, K. A., McKenzie, D.C., Virani, S.A., Stöhr, E.J., Warburton, D.E.R. and Campbell, K. L. (2017) 'Protective effects of acute exercise prior to doxorubicin on cardiac function of breast cancer patients: A proof-of-concept RCT' International Journal of Cardiology. http://dx.doi.org/10.1016/j.ijcard.2017.07.037en_US
dc.identifier.issn0167-5273
dc.identifier.issn1874-1754 (ESSN)
dc.identifier.urihttp://hdl.handle.net/10369/8756
dc.descriptionThis article was published in International Journal of Cardiology on 14 July 2017 (online), available at http://dx.doi.org/10.1016/j.ijcard.2017.07.037en_US
dc.description.abstractBackground: Preclinical studies have reported that a single treadmill session performed 24 h prior to doxorubicin provides cardio-protection. We aimed to characterize the acute change in cardiac function following an initial doxorubicin treatment in humans and determine whether an exercise session performed 24 h prior to treatment changes this response. Methods: Breast cancer patients were randomized to either 30 minutes of vigorous-intensity exercise 24 h prior to the first doxorubicin treatment (n=13), or no vigorous exercise for 72 h prior to treatment (control, n=11). Echocardiographically-derived left ventricular volumes, longitudinal strain, twist, E/A ratio, and circulating NT-proBNP, a marker of later cardiotoxicity, were measured before and 24-48 h after the treatment. Results: Following treatment in the control group, NT-proBNP, end-diastolic and stroke volumes, cardiac output, E/A ratio, strain, diastolic strain rate, twist, and untwist velocity significantly increased (all p≤0.01). Whereas systemic vascular resistance (p<0.01) decreased, and ejection fraction (p=0.02) and systolic strain rate (p<0.01) increased in the exercise group only. Relative to control, the exercise group had a significantly lower NT-proBNP (p<0.01) and a 46% risk reduction of exceeding the cut-point used to exclude acute heart failure. Conclusion: The first doxorubicin treatment is associated with acutely increased NT-proBNP, echocardiographic parameters of myocardial relaxation, left ventricular volume overload, and changes in longitudinal strain and twist opposite in direction to documented longer-term changes. An exercise session performed 24 h prior to treatment attenuated NT-proBNP release and increased systolic function. Future investigations should verify these findings in a larger cohort and across multiple courses of doxorubicin.en_US
dc.language.isoenen_US
dc.publisherElsevieren_US
dc.relation.ispartofseriesInternational Journal of Cardiology;
dc.subjectdoxorubicinen_US
dc.subjectbreast canceren_US
dc.subjectcardiotoxicityen_US
dc.subjectexerciseen_US
dc.subjectlongitudinal strainen_US
dc.subjectNT-proBNPen_US
dc.titleProtective effects of acute exercise prior to doxorubicin on cardiac function of breast cancer patients: A proof-of-concept RCTen_US
dc.typeArticleen_US
dc.typeacceptedVersion
dcterms.dateAccepted2017-07-12
rioxxterms.funderCardiff Metropolitan Universityen_US
rioxxterms.identifier.projectCardiff Metropolian (Internal)en_US
rioxxterms.versionAMen_US
rioxxterms.versionofrecordhttp://dx.doi.org/10.1016/j.ijcard.2017.07.037
rioxxterms.licenseref.urihttps://creativecommons.org/licenses/by-nc-nd/4.0/en_US
rioxxterms.licenseref.startdate2017-08-23
rioxxterms.publicationdate2017-07-14
dc.date.refFCD2017-08-23
rioxxterms.freetoread.startdate2018-07-14
rioxxterms.funder.project37baf166-7129-4cd4-b6a1-507454d1372een_US


Files in this item

Thumbnail

This item appears in the following collection(s)

Show simple item record