The in vitro effects of cell lysate and temperature variations on biofilm dispersal in P. aeruginosa
Cardiff Metropolitan University
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Pseudomonas aeruginosa is an opportunistic pathogen capable of inflicting a vast range of life- threatening infections. Its significance is important to research, due to its implication of high mortality rates recorded among cystic fibrosis (CF) patients1. Doring et al found that P. aeruginosa can adapt to CF airways and persist as a devastating and lasting infection in about 70% of adults2. The purpose of this study was to investigate the effects of host responses and potential signaling molecules, associated with a viral infection on biofilm dispersal in P. aeruginosa. It aimed to explain the events that influence biofilm dispersion and turns a passive nasopharyngeal commensal into a detrimental opportunist pathogen.
B.Sc. (Hons) degree in Biomedical Science