A Systematic Review of Studies Investigating the Influences of Diet on Neural Inflammatory Diseases
Cardiff Metropolitan University
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Background/objective: Dementia is a neurodegenerative disorder effecting people all around the world due to a mixture of environmental and lifestyle factors. In epidemics diet is hugely associated with causing and preventing neuroinflammation and neurodegeneration, these are known as neuroprotective and neurotoxic factors. The Med diet is widely discussed in relation to dementia. A systematic review will take place to identify causes of dementia related disorders including Alzheimer’s Disease, as a result of dietary factors. Methods: By conducting a systematic approach of searching articles on PubMed, with available odds ratios, it was possible to analyse the data using forest plots which will help convey an understanding of current neuroprotective and neurotoxic factors of the populations diet. The participant size, confidence interval and odds ratio were important when choosing which studies to use in the results to eliminate bias. The required confidence interval: 95%, participant size: >80. Heterogeneous or homogeneous studies were used in order to broaden the range of data and find varied results. Results: eligibility criteria eliminated multiple studies from the database, the search of ‘Alzheimer’s and Diet odds ratios’ found 1593; 5 were used, the search of ‘Diet Dementia odds ratios’ found 1804 articles; 9 were used. Higher adherence of the Mediterranean diet is associated with lower mild cognitive impairment (MCI) and dementia. Obesity is directly associated with decreased cognition and higher risk of dementia. Conclusion: In summary there are many aspects of diet that contribute in causing neurodegeneration, and others that are preventative, studies proved this through odds ratios by showing a significant effect.
BSc (Hons) Biomedical Sciences (Health, Excercise & Nutrition)
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