Exploring the gut microbiome: A meta-analysis investigating the effect of probiotic intervention on glycaemic profiles associated to metabolic disorder.
Ardestani, Branden Arrian
Cardiff Metropolitan University
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The use of probiotics has been adopted as a therapeutic mechanism of intervention amongst many health disorders over the last decade. Recent findings suggest that the gut microbiota harbour an important role in the pathogenesis and metabolic disruption of both Obesity and Type 2 Diabetes Mellitus (T2DM). As an effective strategy to both manage and alter the gut microbiome, probiotics can be utilized to provide specialized health benefits for the individual. The hypotheses surrounding the potential for probiotic intervention to improve metabolic/glycaemic profiling is inconclusive. We searched PubMed identifying a total of 485 participants amongst 6 randomly controlled trials (RCTs) and pooled the data expressed as mean difference (MD) with 95% confidence interval (CI). Heterogeneity was determined through I2 index. Fasting blood glucose (FBG) (n=485) and Fasting Plasma Insulin (n=485) were reported in all trials. Probiotics may alleviate FBG (MD – 0.46 mmol/L , 95% CI , -1.05 , 0.3) and FPI (MD - 1.02Uu/ml ,95% CI , -1.9 , - 0.14 ). Probiotics may benefit glycaemic profiling and thus provide the potential to become a new and exciting method of metabolic control.
BSc (Hons) Sports Biomedicine and Nutrition
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