Is there a place for human fetal-derived stem cells for cell replacement therapy in Huntington's disease?
Precious, Sophie V.
Dunnett, Stephen B.
Rosser, Anne E.
MetadataShow full item record
Huntington's disease (HD) is a neurodegenerative disease that offers an excellent paradigm for cell replacement therapy because of the associated relatively focal cell loss in the striatum. The predominant cells lost in this condition are striatal medium spiny neurons (MSNs). Transplantation of developing MSNs taken from the fetal brain has provided proof of concept that donor MSNs can survive, integrate and bring about a degree of functional recovery in both pre-clinical studies and in a limited number of clinical trials. The scarcity of human fetal tissue, and the logistics of coordinating collection and dissection of tissue with neurosurgical procedures makes the use of fetal tissue for this purpose both complex and limiting. Alternative donor cell sources which are expandable in culture prior to transplantation are currently being sought. Two potential donor cell sources which have received most attention recently are embryonic stem (ES) cells and adult induced pluripotent stem (iPS) cells, both of which can be directed to MSN-like fates, although achieving a genuine MSN fate has proven to be difficult. All potential donor sources have challenges in terms of their clinical application for regenerative medicine, and thus it is important to continue exploring a wide variety of expandable cells. In this review we discuss two less well-reported potential donor cell sources; embryonic germ (EG) cells and fetal neural precursors (FNPs), both are which are fetal-derived and have some properties that could make them useful for regenerative medicine applications.
Precious, S.V., Zietlow, R., Dunnett, S.B., Kelly, C.M. and Rosser, A.E. (2017) 'Is there a place for human fetal-derived stem cells for cell replacement therapy in Huntington's disease?', Neurochemistry International. https://doi.org/10.1016/j.neuint.2017.01.016
This article was published in Neurochemistry International on 27 January 2017 (online) available open access at https://doi.org/10.1016/j.neuint.2017.01.016
Medical Research Council
Showing items related by title, author, subject and abstract.
Medical Terminations of Pregnancy: A Viable Source of Tissue for Cell Replacement Therapy for Neurodegenerative Disorders Torres, Eduardo; Kelly, Claire; Harrison, A. W.; Williams, D.; Weyrauch, U. M.; Lane, E. L.; Kemp, P. J.; Scherf, Caroline; Precious, Sophie; Allen, Nicholas; Penketh, Richard; Amso, Nazar; Dunnett, Stephen; Rosser, Anne (Cognizant Communication Corporation, 2011)"Proof-of-principle" that cell replacement therapy works for neurodegeneration has been reported, but only using donor cells collected from fetal brain tissue obtained from surgical terminations of pregnancy. Surgical ...
Can manipulation of differentiation conditions eliminate proliferative cells from a population of ES cell-derived forebrain cells? Precious, Sophie V.; Kelly, Claire; Allen, Nicholas D.; Rosser, Anne E. (Taylor Francis, 2016-01-11)There is preliminary evidence that implantation of primary fetal striatal cells provides functional benefit in patients with Huntington’s disease, a neurodegenerative condition resulting in loss of medium-sized spiny neurons ...
AN INVESTIGATION INTO HOW NATIONAL UK CHARITIES USE BRANDING AND PROMOTION AS A MEANS OF ESTABLISHING DONOR LOYALTY TO INCREASE INCOME: USING A CASE STUDY OF CANCER RESEARCH UK. Nicholas, Kerry (Cardiff Metropolitan University, 2018-04)The charity marketplace is becoming increasingly saturated and competitive as it continues to experience a trend of growth. Therefore, charities are having to find ways to differentiate themselves, and keep and attract ...