Heart rate and indirect blood pressure responses to four different field anesthetic protocols in wild born captive chimpanzees (pan troglodytes)
Stöhr, Eric J.
Drane, Aimee L.
del Rio, Pablo Rodriguez Lopez
Sanchez, Carols R.
MetadataShow full item record
Limited data are available on hemodynamic responses to anesthetic protocols in wild-born chimpanzees (Pan troglodytes). Accordingly, this study characterized the heart rate (HR) and blood pressure responses to four anesthetic protocols in 176 clinically healthy, wild-born chimpanzees undergoing routine health assessments. Animals were anesthetized with medetomidine–ketamine (MK) (n = 101), tiletamine–zolazepam (TZ) (n = 30), tiletamine–zolazepam–medetomidine (TZM) (n = 24), or medetomidine–ketamine (maintained with isoflurane) (MKI) (n = 21). During each procedure, HR, systolic blood pressure (SBP), and diastolic blood pressure (DBP) were regularly recorded. Data were grouped according to anesthetic protocol, and mean HR, SBP, and DBP were calculated. Differences between mean HR, SBP, and DBP for each anesthetic protocol were assessed using the Kruskall–Wallis test and a Dunn multiple comparisons post hoc analysis. To assess the hemodynamic time course response to each anesthetic protocol, group mean data (±95% confidence interval [CI]) were plotted against time postanesthetic induction. Mean HR (beats/min [CI]) was significantly higher in TZ (86 [80–92]) compared to MKI (69 [61–78]) and MK (62 [60–64]) and in TZM (73 [68–78]) compared to MK. The average SBP and DBP values (mm Hg [CI]) were significantly higher in MK (130 [126–134] and 94 [91–97]) compared to TZ (104 [96–112] and 58 [53–93]) and MKI (113 [103–123] and 78 [69–87]) and in TZM (128 [120–135] and 88 [83–93]) compared to TZ. Time course data were markedly different between protocols, with MKI showing the greatest decline over time. Both the anesthetic protocol adopted and the timing of measurement after injection influence hemodynamic recordings in wild-born chimpanzees and need to be considered when monitoring or assessing cardiovascular health.
Journal of Zoo and Wildlife Medicine;
Atencia, R., Stohr, E.J., Drane, A.L., Stembridge, M., Howatson, G., Lopez del Rio, P.R., Feltrer, Y., Tafon, B., Redrobe, S., Peck, B., Eng, J., Unwin, C.R., Sanchez, C.R. and Shave, R.E. (2017) 'Heart rate and indirect blood pressure responses to four different field anesthetic protocols in wild born captive chimpanzees (pan troglodytes)', Journal of Zoo and Wildlife Medicine, 48(3), pp.636-644
This article was published in Journal of Zoo and Wildlife Medicine on 01 September 2017 (online), available at https://doi.org/10.1638/2016-0181.1
- Sport Research Groups 
Showing items related by title, author, subject and abstract.
The influence of anesthesia with and without medetomidine on cardiac structure and function in sanctuary captive chimpanzees (pan troglodytes) Drane, Aimee L.; Calvi, Thalita; Feltrer, Yedra; Curry, Bryony; Tremblay, Joshua; Milnes, Ellie; Stöhr, Eric J.; Howastan, Glyn; Oxborough, David; Stembridge, Mike; Shave, Rob (American Association of Zoo Vetinarians, 2021)Dependent on timing of assessment, anesthetic agents and specifically medetomidinenegatively impact cardiac function in great apes. The aim of this study was todetermine the influence of tiletamine-zolazepam with and without ...
Cardiac structure and function characterized across age groups and between sexes in healthy wild-born captive chimpanzees (Pan troglodytes) living in sanctuaries Drane, Aimee L.; Atencia, Rebeca; Cooper, Stephen-Mark; Rodriguez, Pablo; Sanchez, Carlos; Simcox, Sarah; Feltrer, Yedra; Peck, Bruce; Eng, Jaclyn; Moittie, Sophie; Unwin, Steve; Howatson, Glyn; Oxborough, David; Stembridge, Mike; Shave, Rob (American Veterinary Medical Association, 2019-06)Objective: To comprehensively characterize cardiac structure and function, from infancy to adulthood, in male and female wild-born captive chimpanzees (Pan troglodytes) living in sanctuaries. Animals: 290 wild-born captive ...
Selection of endurance capabilities and the trade-off between pressure and volume in the evolution of the human heart Shave, Rob; Lieberman, Daniel; Drane, Aimee L.; Brown, Marcel; Batterham, Alan; Worthington, Steven; Atencia, Rebeca; Feltrer, Yedra; Neary, Jennifer; Weiner, Rory; Wasfy, Meagan; Baggish, Aaron L. (National Academy of Sciences, 2019-09-16)Chimpanzees and gorillas, when not inactive, engage primarily in short bursts of resistance physical activity (RPA), such as climbing and fighting, that creates pressure stress on the cardiovascular system. In contrast, ...