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Heart rate and indirect blood pressure responses to four different field anesthetic protocols in wild born captive chimpanzees (pan troglodytes)

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Author
Atencia, Rebeca
Stöhr, Eric J.
Drane, Aimee L.
Stembridge, Mike
Howatson, Glyn
del Rio, Pablo Rodriguez Lopez
Feltrer, Yedra
Tafon, Babila
Redrobe, Sharon
Peck, Bruce
Eng, Jaclyn
Unwin, Steve
Sanchez, Carols R.
Shave, Rob
Date
2017-09-01
Acceptance date
2017-06-04
Type
Article
Publisher
BioOne
ISSN
1937-2825 (ESSN)
Embargoed until
2100-01-01
Metadata
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Abstract
Limited data are available on hemodynamic responses to anesthetic protocols in wild-born chimpanzees (Pan troglodytes). Accordingly, this study characterized the heart rate (HR) and blood pressure responses to four anesthetic protocols in 176 clinically healthy, wild-born chimpanzees undergoing routine health assessments. Animals were anesthetized with medetomidine–ketamine (MK) (n = 101), tiletamine–zolazepam (TZ) (n = 30), tiletamine–zolazepam–medetomidine (TZM) (n = 24), or medetomidine–ketamine (maintained with isoflurane) (MKI) (n = 21). During each procedure, HR, systolic blood pressure (SBP), and diastolic blood pressure (DBP) were regularly recorded. Data were grouped according to anesthetic protocol, and mean HR, SBP, and DBP were calculated. Differences between mean HR, SBP, and DBP for each anesthetic protocol were assessed using the Kruskall–Wallis test and a Dunn multiple comparisons post hoc analysis. To assess the hemodynamic time course response to each anesthetic protocol, group mean data (±95% confidence interval [CI]) were plotted against time postanesthetic induction. Mean HR (beats/min [CI]) was significantly higher in TZ (86 [80–92]) compared to MKI (69 [61–78]) and MK (62 [60–64]) and in TZM (73 [68–78]) compared to MK. The average SBP and DBP values (mm Hg [CI]) were significantly higher in MK (130 [126–134] and 94 [91–97]) compared to TZ (104 [96–112] and 58 [53–93]) and MKI (113 [103–123] and 78 [69–87]) and in TZM (128 [120–135] and 88 [83–93]) compared to TZ. Time course data were markedly different between protocols, with MKI showing the greatest decline over time. Both the anesthetic protocol adopted and the timing of measurement after injection influence hemodynamic recordings in wild-born chimpanzees and need to be considered when monitoring or assessing cardiovascular health.
Journal/conference proceeding
Journal of Zoo and Wildlife Medicine;
Citation
Atencia, R., Stohr, E.J., Drane, A.L., Stembridge, M., Howatson, G., Lopez del Rio, P.R., Feltrer, Y., Tafon, B., Redrobe, S., Peck, B., Eng, J., Unwin, C.R., Sanchez, C.R. and Shave, R.E. (2017) 'Heart rate and indirect blood pressure responses to four different field anesthetic protocols in wild born captive chimpanzees (pan troglodytes)', Journal of Zoo and Wildlife Medicine, 48(3), pp.636-644
URI
http://hdl.handle.net/10369/9180
DOI
https://doi.org/10.1638/2016-0181.1
Description
This article was published in Journal of Zoo and Wildlife Medicine on 01 September 2017 (online), available at https://doi.org/10.1638/2016-0181.1
Closed deposit
Rights
http://www.rioxx.net/licenses/all-rights-reserved
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