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dc.contributor.authorCai, Yuexin
dc.contributor.authorZhou, Qian
dc.contributor.authorYang, Haidi
dc.contributor.authorJiang, Jiajia
dc.contributor.authorZhao, Fei
dc.contributor.authorHuang, Xiayin
dc.contributor.authorMo, Hanjie
dc.contributor.authorChen, Xiaoting
dc.contributor.authorXiong, Hao
dc.contributor.authorChen, Suijun
dc.contributor.authorZhang, Xueyuan
dc.contributor.authorZheng, Yiqing
dc.date.accessioned2017-12-05T16:01:05Z
dc.date.available2017-12-05T16:01:05Z
dc.date.issued2017-11-01
dc.identifier.citationCai YX,, Zhou Q, Yang HD, Jiang JJ, Zhao F, Huang XY, Mo HJ, Chen XT, Xiong H, Chen SJ, Zhang XY, Zheng YQ (2017) 'Logistic Regression Analysis of Factors Influencing the Effectiveness of Intensive Sound Masking Therapy in Patients with Tinnitus', BMJ Open, 7(11):e018050.en_US
dc.identifier.issn2044-6055
dc.identifier.urihttp://hdl.handle.net/10369/9182
dc.descriptionThis article was published in BMJ Open on 01 November 2017, available open access online at http://dx.doi.org/10.1136/bmjopen-2017-018050en_US
dc.description.abstractObjectives: To investigate factors influencing the effectiveness intensive sound masking therapy on tinnitus using Logistic Regression Analysis. Design: The study used a retrospective cross-section analysis. Participants: 102 patients with tinnitus were recruited at the Sun Yat-sen Memorial Hospital of Sun Yat-sen University, China. Intervention: Intensive sound masking therapy was used as an intervention approach for patients with tinnitus. Primary and secondary outcome measures: participants underwent audiological investigations and tinnitus pitch and loudness matching measurements, followed by intensive sound masking therapy. The Tinnitus Handicap Inventory (THI) was used as the outcome measure pre- and post-treatment. Multivariate logistic regression was performed to investigate the association of demographic and audiological factors with effective therapy. Results: According to the THI score changes pre-and post-sound masking intervention, fifty-one participants were categorised into an effective group, the remaining 51 participants were placed in a non-effective group. Those in the effective group were significantly younger than those in the non-effective group (p=0.012). Significantly more participants had flat audiogram configurations in the effective group (p=0.04). Multivariable logistic regression analysis showed that age (OR=0.96, 95% CI: 0.93, 0.99, p=0.007), audiometric configuration (p=0.027) and THI score pre-treatment (OR=1.04, 95% CI: 1.02, 1.07, p<0.001) were significantly associated with therapeutic effectiveness. Further analysis showed that patients with flat audiometric configurations were 5.45 times more likely to respond to intervention than those with high-frequency steeply sloping audiograms (OR=5.45, 95% CI: 1.67, 17.86, p=0.005). Conclusion: Audiometric configuration, age and THI scores appear to be predictive for the effectiveness of sound masking treatment. Gender, tinnitus characteristics and hearing threshold measures seem not to be related to treatment effectiveness. Further randomized control study is needed to provide further evidence of the effectiveness of prognostic factors in tinnitus interventions.en_US
dc.language.isoenen_US
dc.publisherBMJ Publishing Groupen_US
dc.relation.ispartofseriesBMJ Open;
dc.subjectSound Masking; Tinnitus; Audiometric Configuration; Prognostic Factorsen_US
dc.titleLogistic Regression Analysis of Factors Influencing the Effectiveness of Intensive Sound Masking Therapy in Patients with Tinnitusen_US
dc.typeArticleen_US
dc.identifier.doihttp://dx.doi.org/10.1136/bmjopen-2017-018050
dcterms.dateAccepted2017-09-28
rioxxterms.funderCardiff Metropolitan Universityen_US
rioxxterms.identifier.projectCardiff Metropolian (Internal)en_US
rioxxterms.versionVoRen_US
rioxxterms.licenseref.urihttp://creativecommons.org/licenses/by-nc/4.0/en_US
rioxxterms.licenseref.startdate2017-12-05
rioxxterms.funder.project37baf166-7129-4cd4-b6a1-507454d1372een_US


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