The Ability of Exercise-Associated Oxidative Stress toTrigger Redox-Sensitive Signalling Responses
Hughes, Michael G.
MetadataShow full item record
In this review, we discuss exercise as an oxidative stressor, and elucidate the mechanismsand downstream consequences of exercise-induced oxidative stress. Reactive oxygen species(ROS) are generated in the mitochondria of contracting skeletal myocytes; also, their diffusion across the myocyte membrane allows their transport to neighbouring muscle tissue and to other regions of the body. Although very intense exercise can induce oxidative damage within myocytes,the magnitudes of moderate-intensity exercise-associated increases in ROS are quite modest(~two-fold increases in intracellular and extracellular ROS concentrations during exercise), and so the effects of such increases are likely to involve redox-sensitive signalling effects rather than oxidative damage. Therefore, the responses of muscle and non-muscle cells to exercise-associated redox-sensitive signalling effects will be reviewed; for example, transcription factors such as Peroxisome Proliferator Activated Receptor-gamma (PPARγ) and Liver X-Receptor-alpha (LXRα)comprise redox-activable signalling systems, and we and others have reported exercise-associated modulation of PPARγand/or LXRα-regulated genes in skeletal myocyte and in non-muscle cell-types such as monocyte-macrophages. Finally, the consequences of such responses in the context of management of chronic inflammatory conditions, and also their implications for the design of exercise training programmes (particularly the use of dietary antioxidants alongside exercise) will be discussed.
Webb, R., Hughes, M.G., Thomas A.W. and Morris K. (2017) 'The Ability of Exercise-Associated Oxidative Stress toTrigger Redox-Sensitive Signalling Responses', Antioxidants, 6(3), pp.1-21
This article was published open access in Antioxidants on 10 August 2017, available at https://doi.org/10.3390/antiox6030063
Showing items related by title, author, subject and abstract.
Evaluation of sampling methodologies for use in investigation of the health benefits of community-based exercise Thwin, Phway Phway (Cardiff Metropolitan University, 2011)Low- intensity exercise exerts therapeutic benefits on molecular pathways controlling reverse cholesterol transport, arterial stiffness and monocyte polarisation via transcription factors peroxisome proliferator-activated ...
Exercise-induced immunosuppression: roles of reactive oxygen species and 5-AMP-activated protein kinase dephosphorylation within immune cells Hughes, Michael G.; Potter, Stephen; Sims, Craig; Butcher, Lee; Davies, Nia; Verheggen, Kenneth; Jones, Ken; Thomas, Andrew; Webb, Richard (American Physiological Society, 2010)We previously proposed 5′-AMP-activated protein kinase (AMPK) dephosphorylation within immune cells as an intracellular mechanism linking exercise and immunosuppression. In this study, AMPK phosphorylation underwent transient ...
Ashton, Tony (Cardiff Metropolitan University, 1998)Electron spin resonance (ESR) evidence concerning free radical production by exercise has been confined to animals. This thesis describes a methodology to measure free radicals using ESR in the venous circulation of healthy ...