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dc.contributor.authorLord, Rachel
dc.contributor.authorMacleod, David
dc.contributor.authorGeorge, Keith
dc.contributor.authorOxborough, David
dc.contributor.authorShave, Rob
dc.contributor.authorStembridge, Mike
dc.date.accessioned2018-02-15T11:57:04Z
dc.date.available2018-02-15T11:57:04Z
dc.date.issued2018-01-18
dc.identifier.citationLord, R., MacLeod, D., George, K., Oxborough, D., Shave, R. and Stembridge, M. (2018) 'Reduced left ventricular filling following blood volume extraction does not result in compensatory augmentation of cardiac mechanics', Experimental physiology. doi :10.1113/EP086761en_US
dc.identifier.issn0958-0670
dc.identifier.issn1469-445X (ESSN)
dc.identifier.urihttp://hdl.handle.net/10369/9278
dc.descriptionThis article was published in Experimental Physiology on 18 January 2018 online, available at http://dx.doi.org/10.1113/EP086761en_US
dc.description.abstractAn acute non-invasive reduction in preload has been shown to augment cardiac mechanics to maintain stroke volume and cardiac output. Such interventions induce concomitant changes in heart rate, whereas blood volume extraction reduces preload without changes in heart rate. Therefore, the purpose of this study was to determine whether a preload reduction in isolation resulted in augmented stroke volume achieved via enhanced cardiac mechanics. Nine healthy volunteers (four female, age 29 ± 11 years) underwent echocardiography for the assessment of left ventricular (LV) volumes and mechanics in a supine position at baseline and end extraction after the controlled removal of 25% of total blood volume (1062 ± 342 ml). Arterial blood pressure was monitored continuously by a pressure transducer attached to an indwelling radial artery catheter. Heart rate and total peripheral resistance were unchanged from baseline to end extraction, but systolic blood pressure was reduced (from 148 to 127 mmHg). From baseline to end extraction there were significant reductions in left ventricular end-diastolic volume (from 89 to 71 ml) and stroke volume (from 56 to 37 ml); however, there was no change in LV twist, basal or apical rotation. In contrast, LV longitudinal strain (from −20 to −17%) and basal circumferential strain (from −22 to −19%) were significantly reduced from baseline to end extraction. In conclusion, a reduction in preload during blood volume extraction does not result in compensatory changes in stroke volume or cardiac mechanics. Our data suggest that LV strain is dependent on LV filling and consequent geometry, whereas LV twist could be mediated by heart rate.en_US
dc.language.isoenen_US
dc.publisherWileyen_US
dc.relation.ispartofseriesExperimental Physiology;
dc.titleReduced left ventricular filling following blood volume extraction does not result in compensatory augmentation of cardiac mechanicsen_US
dc.typeArticleen_US
dc.identifier.doihttp://dx.doi.org/10.1113/EP086761
dcterms.dateAccepted2018-01-15
rioxxterms.funderCardiff Metropolitan Universityen_US
rioxxterms.identifier.projectCardiff Metropolian (Internal)en_US
rioxxterms.versionAMen_US
rioxxterms.licenseref.urihttp://www.rioxx.net/licenses/under-embargo-all-rights-reserveden_US
rioxxterms.licenseref.startdate2019-01-18
rioxxterms.freetoread.startdate2019-01-18
rioxxterms.funder.project37baf166-7129-4cd4-b6a1-507454d1372een_US


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