Dynamic viscoelasticity and surface properties of porcine left anterior descending coronary arteries
Freij, Jenny M.
Espino, Daniel M.
MetadataShow full item record
The aim of this study was, for the first time, to measure and compare quantitatively the viscoelastic properties and surface roughness of coronary arteries. Porcine left anterior descending coronary arteries were dissected ex vivo. Viscoelastic properties were measured longitudinally using dynamic mechanical analysis, for a range of frequencies from 0.5 to 10 Hz. Surface roughness was calculated following three-dimensional reconstructed of surface images obtained using an optical microscope. Storage modulus ranged from 14.47 to 25.82 MPa, and was found to be frequency-dependent, decreasing as the frequency increased. Storage was greater than the loss modulus, with the latter found to be frequency-independent with a mean value of 2.10 ± 0.33 MPa. The circumferential surface roughness was significantly greater (p < 0.05) than the longitudinal surface roughness, ranging from 0.73 to 2.83 and 0.35 to 0.92 µm, respectively. However, if surface roughness values were corrected for shrinkage during processing, circumferential and longitudinal surface roughness were not significantly different (1.04 ± 0.47, 0.89 ± 0.27 µm, respectively; p > 0.05). No correlation was found between the viscoelastic properties and surface roughness. It is feasible to quantitatively measure the viscoelastic properties of coronary arteries and the roughness of their endothelial surface.
Cardiovascular Engineering and Technology;
Burton, H.E., Freij, J.M. and Espino, D.M. (2017) 'Dynamic viscoelasticity and surface properties of porcine left anterior descending coronary arteries', Cardiovascular Engineering and Technology, 8(1), pp.41-56
This article was published in Cardiovascular Engineering and Technology on 12 December 2016 (online), available at http://dx.doi.org/10.1007/s13239-016-0288-4
HEB is funded by an Engineering and Physical Sciences Research Council scholarship 21 [M114612B]. The materials testing equipment used in this study was funded by an Arthritis 22 Research UK grant [H0671]. Th is study was partly funded by an Innovation and Research 23 Award from the Institute of Physics and Engineering in Medicine .
Showing items related by title, author, subject and abstract.
Effects of freezing, fixation and dehydration on surface roughness properties of porcine left anterior descending coronary arteries Burton, Hanna; Williams, Richard; Espino, Daniel (Elsevier, 2017-06-22)Background To allow measurements of surface roughness to be made of coronary arteries using various imaging techniques, chemical processing, such as fixation and dehydration, is commonly used. Standard protocols suggest ...
Burton, Hanna; Espino, Daniel (Hindawi, 2019-01-23)Background. Surface roughness can be used to identify disease within biological tissues. Quantifying surface roughness in the coronary arteries aids in developing treatments for coronary heart disease. This study investigates ...
Objective Uniaxial Identification of Transition Points in Non-Linear Materials: Sample Application to Porcine Coronary Arteries and the Dependency of Their Pre- and Post-Transitional Moduli with Position Freij, Jenny M.; Burton, Hanna; Espino, Daniel M. (Springer, 2018-11-28)This study aimed to develop an objective method for the elastic characterisation of pre- and post-transitional moduli of left anterior descending (LAD) porcine coronary arteries. Methods Eight coronary arteries were ...