UBC-Nepal expedition: markedly lower cerebral blood flow in high-altitude Sherpa children compared with children residing at sea level

Gweld/ agor
Awdur
Fluck, Daniela
Morris, Laura
Niroula, Shailesh
Tallon, Christine
Sherpa, Kami T.
Stembridge, Mike
Ainslie, Philip
McManus, Ali
Dyddiad
2017-10-01Dyddiad derbyn
2017-05-30
Math
Article
Cyhoeddwr
American Physiological Society
ISSN
1522-1601
Metadata
Dangos cofnod eitem llawnCrynodeb
Developmental cerebral hemodynamic adaptations to chronic high-altitude exposure, such as in the Sherpa population, are largely unknown. To examine hemodynamic adaptations in the developing human brain, we assessed common carotid (CCA), internal carotid (ICA), and vertebral artery (VA) flow and middle cerebral artery (MCA) velocity in 25 (9.6 ± 1.0 yr old, 129 ± 9 cm, 27 ± 8 kg, 14 girls) Sherpa children (3,800 m, Nepal) and 25 (9.9 ± 0.7 yr old, 143 ± 7 cm, 34 ± 6 kg, 14 girls) age-matched sea level children (344 m, Canada) during supine rest. Resting gas exchange, blood pressure, oxygen saturation and heart rate were assessed. Despite comparable age, height and weight were lower (both P < 0.01) in Sherpa compared with sea level children. Mean arterial pressure, heart rate, and ventilation were similar, whereas oxygen saturation (95 ± 2 vs. 99 ± 1%, P < 0.01) and end-tidal Pco2 (24 ± 3 vs. 36 ± 3 Torr, P < 0.01) were lower in Sherpa children. Global cerebral blood flow was ∼30% lower in Sherpa compared with sea level children. This was reflected in a lower ICA flow (283 ± 108 vs. 333 ± 56 ml/min, P = 0.05), VA flow (78 ± 26 vs. 118 ± 35 ml/min, P < 0.05), and MCA velocity (72 ± 14 vs. 88 ± 14 cm/s, P < 0.01). CCA flow was similar between Sherpa and sea level children (425 ± 92 vs. 441 ± 81 ml/min, P = 0.52). Scaling flow and oxygen uptake for differences in vessel diameter and body size, respectively, led to the same findings. A lower cerebral blood flow in Sherpa children may reflect specific cerebral hemodynamic adaptations to chronic hypoxia.
Cyfnodolyn/trafodion cynhadledd
Journal of Applied Physiology;
Dyfyniad
Flück, D., Morris, L.E., Niroula, S., Tallon, C.M., Sherpa, K.T., Stembridge, M., Ainslie, P.N. and McManus, A.M., 2017. UBC-Nepal expedition: markedly lower cerebral blood flow in high-altitude Sherpa children compared with children residing at sea level. Journal of Applied Physiology, 123(4), pp.1003-1010.
Dynodwr Gwrthrych Digidol (DOI)
https://doi.org/10.1152/japplphysiol.00292.2017Disgrifiad
This article was published in Journal of Applied Physiology on 1 October 2017, available at https://doi.org/10.1152/japplphysiol.00292.2017
Nawdd
Cardiff Metropolitan University (Grant ID: Cardiff Metropolian (Internal))
Casgliadau
- Sport Research Groups [1083]
Eitemau perthynol
Yn dangos eitemau sy’n perthyn drwy deitl, awdur, pwnc a chrynodeb.
-
UBC‐nepal expedition: Phenotypical evidence for evolutionary adaptation in the control of cerebral blood flow and oxygen delivery at high altitude
Hoiland, Ryan; Howe, Connor; Carter, Howard; Tremblay, Joshua; Willie, Chris; Donnelly, Joseph; MacLeod, David; Gasho, Chris; Stembridge, Mike; Boulet, Lindsey; Niroula, Shailesh; Ainslie, Philip (Wiley, 2019-04-26)Debilitating side effects of hypoxia manifest within the central nervous system; however, high‐altitude natives of the Tibetan plateau, the Sherpa, experience negligible cerebral effects compared to lowland natives at ... -
UBC-Nepal Expedition: Cerebrovascular responses to exercise in Sherpa children residing at high altitude
Rieger, Mathew; Nowak-Fluck, Daniela; Morris, Laura; Niroula, Shailesh; Sherpa, Kami; Tallon, Christine; Stembridge, Mike; Ainslie, Philip; McManus, Ali (Mary Ann Liebert, Inc., publishers, 2019-01-16)Understanding the process of successful adaptation to high altitude provides valuable insight into the pathogenesis of conditions associated with impaired oxygen uptake and utilization. Prepubertal children residing at low ... -
Ventricular structure, function and mechanics at high altitude: chronic remodelling in Sherpa verses short-term lowlander adaptation.
Awdur anhysbys (American Physiological Society, 2014-08-01)Short-term, high-altitude (HA) exposure raises pulmonary artery systolic pressure (PASP) and decreases left-ventricular (LV) volumes. However, relatively little is known of the long-term cardiac consequences of prolonged ...