Show simple item record

dc.contributor.authorHansen, Alex B.
dc.contributor.authorHoiland, Ryland L.
dc.contributor.authorLewis, Nia C. S.
dc.contributor.authorTymko, Michael M.
dc.contributor.authorTremblay, Joshua C.
dc.contributor.authorStembridge, Mike
dc.contributor.authorNowak-Fluck, Daniela
dc.contributor.authorCarter, Howard H.
dc.contributor.authorBailey, Damian M.
dc.contributor.authorAinslie, Philip
dc.date.accessioned2018-02-27T11:06:32Z
dc.date.available2018-02-27T11:06:32Z
dc.date.issued2018-02-10
dc.identifier.citationHansen, A.B., Hoiland, R.L., Lewis, N., Tymko, M.M., Tremblay, J.C., Stembridge, M., Nowak‐Flück, D., Carter, H.H., Bailey, D.M. and Ainslie, P.N. (2018) 'UBC‐Nepal expedition: The use of oral antioxidants does not alter cerebrovascular function at sea‐level or high‐altitude', Experimental Physiology. https://doi.org/10.1113/EP086887en_US
dc.identifier.issn0958-0670
dc.identifier.issn1469-445X (ESSN)
dc.identifier.urihttp://hdl.handle.net/10369/9305
dc.descriptionThis article was published in Experimental Physiology on 10 February 2018 (online), available at https://doi.org/10.1113/EP086887en_US
dc.description.abstractHypoxia is associated with an increased systemic and cerebral formation of free radicals and associated reactants that may be linked to impaired cerebral vascular function a neurological sequela. To what extent oral antioxidants prophylaxis impacts cerebrovascular function in humans throughout the course of acclimatization to the hypoxia of terrestrial high-altitude has not been examined. Thus, the purpose of the current study was to examine the influence of orally ingested antioxidants at clinically relevant doses (vitamin C, E, and alpha-lipoic acid) on cerebrovascular regulation at sea-level (344 m; n = 12; female n = 2 participants), and at high altitude (5050 m; n = 9; female n = 2), in a randomized, placebo-controlled, and double-blinded crossover design. Hypercapnic and hypoxic cerebrovascular reactivity tests of the internal carotid (ICA)] were conducted at sea-level, while global and regional cerebral blood flow [i.e. ICA and vertebral artery (VA)] were assessed after 10–12 days following arrival at 5050 m. At sea-level, acute administration of antioxidants did not alter cerebral hypoxic cerebrovascular reactivity (pre vs. post: 1.5 ± 0.7 vs. 1.2 ± 0.8 %∆CBF/-%∆SpO2; P = 0.96), or cerebral hypercapnic cerebrovascular reactivity (pre vs. post: 5.7 ± 2.0 vs. 5.8 ± 1.9 %∆CBF/∆mmHg; P = 0.33). Furthermore, global cerebral blood flow (P = 0.43), as well as cerebral vascular conductance (ICA P = 0.08; VA P = 0.32), were unaltered at 5050 m following antioxidant administration. In conclusion, these data show that an oral antioxidant cocktail known to attenuate systemic oxidative stress failed to alter cerebrovascular function at sea-level and cerebral blood flow during acclimatization to high-altitude.en_US
dc.language.isoenen_US
dc.publisherWileyen_US
dc.relation.ispartofseriesExperimental Physiology;
dc.subjectantioxidantsen_US
dc.subjectcerebral blood flowen_US
dc.subjectoxidative stressen_US
dc.titleUBC-Nepal expedition: The use of oral antioxidants does not alter cerebrovascular function at sea-level or high-altitudeen_US
dc.typeArticleen_US
dc.identifier.doihttps://doi.org/10.1113/EP086887
dcterms.dateAccepted2018-02-05
rioxxterms.funderCardiff Metropolitan Universityen_US
rioxxterms.identifier.projectCardiff Metropolian (Internal)en_US
rioxxterms.versionAMen_US
rioxxterms.licenseref.urihttp://www.rioxx.net/licenses/under-embargo-all-rights-reserveden_US
rioxxterms.licenseref.startdate2019-02-10
rioxxterms.freetoread.startdate2019-02-10
rioxxterms.funder.project37baf166-7129-4cd4-b6a1-507454d1372een_US


Files in this item

Thumbnail

This item appears in the following collection(s)

Show simple item record