Antibiotic resistance among Ureaplasma spp isolates: cause for concern?
Beeton, Michael L.
Oxford University Press
MetadataShow full item record
There is growing global concern regarding the rise of antibiotic-resistant organisms. Many of these reports have focused on various Gram-positive and Gram-negative pathogens, with little attention to the genus Ureaplasma. Ureaplasma spp. are associated with numerous infectious diseases affecting pregnant women, neonates and the immunocompromised. Treatment options are extremely limited due to high levels of intrinsic resistance resulting from the unique physiology of these organisms and further restricted in cases of the developing fetus or neonate, often limiting therapeutic options to predominantly macrolides or rarely fluoroquinolones. The increasing presence of macrolide- and fluoroquinolone-resistant strains among neonatal infections may result in pan-drug resistance and potentially untreatable conditions. Here, we review the requirements for accurate measurement of antimicrobial susceptibility, provide a comprehensive review of the antimicrobial resistance (AMR) for Ureaplasma species in the literature and contextualize these results relative to some investigators' reliance on commercial kits that are not CLSI compliant when determining AMR. The dramatic variation in the resistance patterns and impact of high levels of AMR amongst neonatal populations suggests the need for continued surveillance. Commercial kits represent an excellent tool for initial antibiotic susceptibility determination and screening. However, AMR reporting must utilize internationally standardized methods, as high-titre samples, or Mycoplasma hominis-contaminated samples routinely give false AMR results. Furthermore, there is a requirement for future reports to determine the underlying AMR mechanisms and determine whether expanding AMR is due to spontaneous mutation, transmission of resistance genes on mobile elements or selection and expansion of resistant clones.
Journal of Antimicrobial Chemotherapy;
Beeton, M. and Spiller, O.B. (2017) 'Antibiotic resistance among Ureaplasma spp isolates: cause for concern?', Journal of Antimicrobial Chemotherapy, 72(2), pp.330-337
This article was published in Journal of Antimicrobial Chemotherapy in October 2016 (online), available at https://doi.org/10.1093/jac/dkw425
Showing items related by title, author, subject and abstract.
Antimicrobial activity of Manuka honey against antibiotic resistant strains of the cell wall free bacteria Ureaplasma parvum and Ureaplasma urealyticum Hillitt, K.L.; Jenkins, Rowena; Spiller, O.B.; Beeton, Michael L. (Wiley, 2016-12-19)The susceptibility of the cell-wall free bacterial pathogens Ureaplasma spp. to Manuka honey was examined. The minimum inhibitory concentration (MIC) of Manuka honey for four Ureaplasma urealyticum and four Ureaplasma ...
Antibiotic resistance among clinical Ureaplasma isolates recovered from neonates in England and Wales between 2007 and 2013 Beeton, Michael L.; Chalker, Victoria J.; Jones, Lucy C.; Maxwell, Nicola C.; Spiller, O. Brad (American Society for Microbiology, 2015)Ureaplasma spp. are associated with numerous clinical sequelae with treatment options being limited due to patient and pathogen factors. This report examines the prevalence and mechanisms of antibiotic resistance among ...
THE ACUTE EFFECTS OF ASSISTED AND RESISTED PLYOMETRIC EXERCISES AS POTENTIATING EXERCISES FOR VERTICAL JUMP PERFORMANCE Shield, Callum (Cardiff Metropolitan University, 2015)Aim: The aim of the present study was to investigate the acute effects of assisted and resisted plyometric exercises as potentiating exercises for vertical jump performance (VJP). Method: 11 male university level trained ...