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dc.contributor.authorCuthbertson, Daniel
dc.contributor.authorShojaee-Moradie, Fariba
dc.contributor.authorSprung, Victoria
dc.contributor.authorJones, Helen
dc.contributor.authorPugh, Christopher J. A.
dc.contributor.authorRichardson, Paul
dc.contributor.authorKemp, Graham
dc.contributor.authorBarrett, Mark
dc.contributor.authorJackson, Nicola
dc.contributor.authorThomas, Louise
dc.contributor.authorBell, Jimmy
dc.contributor.authorUmpleby, Margot
dc.date.accessioned2018-03-14T16:30:25Z
dc.date.available2018-03-14T16:30:25Z
dc.date.issued2015-12-09
dc.identifier.citationCuthbertson, D.J., Shojaee-Moradie, F., Sprung, V.S., Jones, H., Pugh, C.J., Richardson, P., Kemp, G.J., Barrett, M., Jackson, N.C., Thomas, E.L., Bell, J.D. & Umpleby, M. (2016) 'Dissociation between exercise-induced reduction in liver fat and changes in hepatic and peripheral glucose homoeostasis in obese patients with non-alcoholic fatty liver disease', Clinical Science, 130(2), pp.93-104.
dc.identifier.issn0143-5221
dc.identifier.issn1470-8736 (online)
dc.identifier.urihttp://hdl.handle.net/10369/9364
dc.descriptionThis article was published in Clinical Science available at https://doi.org/10.1042/CS20150447
dc.description.abstractNon-alcoholic fatty liver disease (NAFLD) is associated with multi-organ (hepatic, skeletal muscle, adipose tissue) insulin resistance (IR). Exercise is an effective treatment for lowering liver fat but its effect on IR in NAFLD is unknown. We aimed to determine whether supervised exercise in NAFLD would reduce liver fat and improve hepatic and peripheral (skeletal muscle and adipose tissue) insulin sensitivity. Sixty nine NAFLD patients were randomized to 16 weeks exercise supervision (n=38) or counselling (n=31) without dietary modification. All participants underwent MRI/spectroscopy to assess changes in body fat and in liver and skeletal muscle triglyceride, before and following exercise/counselling. To quantify changes in hepatic and peripheral insulin sensitivity, a pre-determined subset (n=12 per group) underwent a two-stage hyperinsulinaemic euglycaemic clamp pre- and post-intervention. Results are shown as mean [95% confidence interval (CI)]. Fifty participants (30 exercise, 20 counselling), 51 years (IQR 40, 56), body mass index (BMI) 31 kg/m2 (IQR 29, 35) with baseline liver fat/water % of 18.8% (IQR 10.7, 34.6) completed the study (12/12 exercise and 7/12 counselling completed the clamp studies). Supervised exercise mediated a greater reduction in liver fat/water percentage than counselling [Δ mean change 4.7% (0.01, 9.4); P<0.05], which correlated with the change in cardiorespiratory fitness (r=–0.34, P=0.0173). With exercise, peripheral insulin sensitivity significantly increased (following high-dose insulin) despite no significant change in hepatic glucose production (HGP; following low-dose insulin); no changes were observed in the control group. Although supervised exercise effectively reduced liver fat, improving peripheral IR in NAFLD, the reduction in liver fat was insufficient to improve hepatic IR.en_US
dc.language.isoenen_US
dc.publisherPortland Pressen_US
dc.relation.ispartofseriesClinical Science;
dc.titleDissociation between exercise-induced reduction in liver fat and changes in hepatic and peripheral glucose homoeostasis in obese patients with non-alcoholic fatty liver diseaseen_US
dc.typeArticleen_US
dc.identifier.doihttps://doi.org/10.1042/CS20150447
dcterms.dateAccepted2015-09-30
rioxxterms.versionAMen_US
rioxxterms.licenseref.urihttp://www.rioxx.net/licenses/all-rights-reserveden_US
rioxxterms.licenseref.startdate2018-03-14


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