• English
    • Welsh
  • English 
    • English
    • Welsh
  • Login
Search DSpace:
  • Home
  • Research at Cardiff Met
  • Library Services
  • Contact Us
View item 
  • DSpace home
  • Cardiff School of Sport and Health Sciences
  • Sport Research Groups
  • View item
  • DSpace home
  • Cardiff School of Sport and Health Sciences
  • Sport Research Groups
  • View item
JavaScript is disabled for your browser. Some features of this site may not work without it.

Ectopic lipid storage in non-alcoholic fatty liver disease is not mediated by impaired mitochondrial oxidative capacity in skeletal muscle

Thumbnail
View/open
Author's post-print (320.2Kb)
Author
Cuthbertson, Daniel
Irwin, Andrew
Sprung, Victoria
Jones, Helen
Pugh, Christopher J. A.
Daousi, Christina
Adams, Valerie
Bimson, William
Shojaee-Moradie, Fariba
Richardson, Paul
Umpleby, Margot
Wilding, John
Kemp, Graham
Date
2014-12
Acceptance date
2014-04-14
Type
Article
Publisher
Portland Press
ISSN
0143-5221
1470-8736 (online)
Metadata
Show full item record
Abstract
Non-alcoholic fatty liver disease (NAFLD), characterized by lipid deposition within the liver [intrahepatocellular lipid (IHCL)], is associated with insulin resistance and the metabolic syndrome (MS). It has been suggested that impaired skeletal muscle mitochondrial function may contribute to ectopic lipid deposition, and the associated MS, by altering post-prandial energy storage. To test this hypothesis, we performed a cross-sectional study of 17 patients with NAFLD [mean±S.D.; age, 45±11 years; body mass index (BMI), 31.6±3.4 kg/m2] and 18 age- and BMI-matched healthy controls (age, 44±11 years; BMI, 30.5±5.2 kg/m2). We determined body composition by MRI, IHCL and intramyocellular (soleus and tibialis anterior) lipids (IMCLs) by proton magnetic resonance spectroscopy (1H-MRS) and skeletal muscle mitochondrial function by dynamic phosphorus magnetic resonance spectroscopy (31P-MRS) of quadriceps muscle. Although matched for BMI and total adiposity, after statistical adjustment for gender, patients with NAFLD (defined by IHCL ≥ 5.5%) had higher IHCLs (25±16% compared with 2±2%; P<0.0005) and a higher prevalence of the MS (76% compared with 28%) compared with healthy controls. Despite this, the visceral fat/subcutaneous fat ratio, IMCLs and muscle mitochondrial function were similar between the NAFLD and control groups, with no significant difference in the rate constants of post-exercise phosphocreatine (PCr) recovery (1.55±0.4 compared with 1.51±0.4 min−1), a measure of muscle mitochondrial function. In conclusion, impaired muscle mitochondrial function does not seem to underlie ectopic lipid deposition, or the accompanying features of the MS, in patients with NAFLD.
Journal/conference proceeding
Clinical Science;
Citation
Cuthbertson, D.J., Irwin, A., Sprung, V.S., Jones, H., Pugh, C.J., Daousi, C., Adams, V.L., Bimson, W.E., Shojaee-Moradie, F., Richardson, P.,Umpleby, A.M., Wilding, J. & Kemp, G. (2014) 'Ectopic lipid storage in Non-Alcoholic Fatty Liver Disease is not mediated by impaired mitochondrial oxidative capacity in skeletal muscle', Clinical Science, 127(12), pp.655-663
URI
http://hdl.handle.net/10369/9365
DOI
https://doi.org/10.1042/CS20130404
Description
This item was published in Clinical Science in December 2014, available at https://doi.org/10.1042/CS20130404
Collections
  • Sport Research Groups [1094]

Related items

Showing items related by title, author, subject and abstract.

  • Thumbnail

    Exercise training reverses endothelial dysfunction in nonalcoholic fatty liver disease 

    Pugh, Christopher J. A.; Sprung, Victoria S.; Kemp, Graham J.; Richardson, Paul; Shojaee-Moradie, Fariba; Umpleby, A. Margot; Green, Daniel J.; Cable, N. Timothy; Jones, Helen; Cuthbertson, Daniel J. (American Physiological Society, 2014-11-01)
    Nonalcoholic fatty liver disease (NAFLD) is an independent risk factor for cardiovascular disease (CVD). Endothelial dysfunction is an early manifestation of atherosclerosis and an important prognostic marker for future ...
  • Thumbnail

    Dissociation between exercise-induced reduction in liver fat and changes in hepatic and peripheral glucose homoeostasis in obese patients with non-alcoholic fatty liver disease 

    Cuthbertson, Daniel; Shojaee-Moradie, Fariba; Sprung, Victoria; Jones, Helen; Pugh, Christopher J. A.; Richardson, Paul; Kemp, Graham; Barrett, Mark; Jackson, Nicola; Thomas, Louise; Bell, Jimmy; Umpleby, Margot (Portland Press, 2015-12-09)
    Non-alcoholic fatty liver disease (NAFLD) is associated with multi-organ (hepatic, skeletal muscle, adipose tissue) insulin resistance (IR). Exercise is an effective treatment for lowering liver fat but its effect on IR ...
  • Thumbnail

    Endothelial dysfunction in hyperandrogenic polycystic ovary syndrome is not explained by either obesity or ectopic fat deposition 

    Sprung, Victoria; Jones, Helen; Pugh, Christopher J. A.; Aziz, Nabil F.; Daousi, Christina; Kemp, Graham; Green, Daniel; Cable, Timothy; Cuthbertson, Daniel J. (Portland Press, 2014-01-31)
    PCOS (polycystic ovary syndrome) is associated with IR (insulin resistance), increased visceral fat and NAFLD (non-alcoholic fatty liver disease) all of which may contribute to endothelial dysfunction, an early marker of ...

Browse

DSpace at Cardiff MetCommunities & CollectionsBy issue dateAuthorsTitlesSubjectsThis collectionBy issue dateAuthorsTitlesSubjects

My Account

Login

Statistics

Most Popular ItemsStatistics by CountryMost Popular Authors

DSpace software copyright © 2002-2015  DuraSpace
Contact us | Send feedback | Administrator