• English
    • Welsh
  • English 
    • English
    • Welsh
  • Login
Search DSpace:
  • Home
  • Research at Cardiff Met
  • Library Services
  • Contact Us
View item 
  • DSpace home
  • Cardiff School of Sport and Health Sciences
  • Sport Research Groups
  • View item
  • DSpace home
  • Cardiff School of Sport and Health Sciences
  • Sport Research Groups
  • View item
JavaScript is disabled for your browser. Some features of this site may not work without it.

Exercise training and artery function in humans: nonresponse and its relationship to cardiovascular risk factors

Thumbnail
Author
Green, Daniel
Eijsvogels, Thijs
Bouta, Yvette
Malorana, Andrew
Naylor, Louise
Scholten, Ralph
Spaanderman, Marc
Pugh, Christopher J. A.
Sprung, Victoria
Schreuder, Tim
Jones, Helen
Cable, Tim
Hopman, Marla
Thijssen, Dick
Date
2014-06-19
Type
Article
Publisher
American Physiological Society
ISSN
8750-7587
Metadata
Show full item record
Abstract
The objectives of our study were to examine1) the proportion of responders and nonresponders to exercise training in terms of vascular function;2) a priori factors related to exercise training induced changes in conduit artery function, and3) the contribution of traditional cardiovascular risk factors to exercise-induced changes in artery function. We pooled data from our laboratories involving 182 subjects who underwent supervised, large-muscle group, endurance-type exercise training interventions with pre-/posttraining measures of flow-mediated dilation (FMD%) to assess artery function. All studies adopted an identical FMD protocol (5-min ischemia, distal cuffinflation), contemporary echo-Doppler methodology, and observer-independent automated analysis. Linear regression analysis was used to identify factors contributing to changes in FMD%. We found that cardiopulmonary fitness improved, and weight, body mass index(BMI), cholesterol, and mean arterial pressure (MAP) decreased after training, while FMD% increased in 76% of subjects (P 0.001).Training-induced increase in FMD% was predicted by lower bodyweight ( 0.212), lower baseline FMD% ( 0.469), lower training frequency ( 0.256), and longer training duration ( 0.367) (combined:P 0.001,r 0.63). With the exception of a modest correlation with total cholesterol (r 0.243,P 0.01), changes in traditional cardiovascular risk factors were not significantly related to changes in FMD% (P 0.05). In conclusion, we found that, while some subjects do not demonstrate increases following exercise training, improvement in FMD% is present in those with lower pretraining body weight and endothelial function. Moreover, exercise training-induced change in FMD% did not correlate with changes in traditional cardiovascular risk factors, indicating that some cardioprotective effects of exercise training are independent of improvement in risk factors
Journal/conference proceeding
Journal of Applied Physiology;
Citation
Green, D.J., Eijsvogels, T., Bouts, Y.M., Maiorana, A.J., Naylor, L.H., Scholten, R.R., Spaanderman, M.E., Pugh, C.J., Sprung, V.S., Schreuder, T., Jones, H., Cable, T., Hopman, M., Thijssen, D. (2014) 'Exercise training and artery function in humans: nonresponse and its relationship to cardiovascular risk factors', Journal of Applied Physiology, 117(4), pp.345-352
URI
http://hdl.handle.net/10369/9366
DOI
https://doi.org/10.1152/japplphysiol.00354.2014
Description
Copy not available from this repository.
Collections
  • Sport Research Groups [1088]

Related items

Showing items related by title, author, subject and abstract.

  • Thumbnail

    Acute Responses and Chronic Adaptations of the Arterial System to Resistance Exercise 

    Black, Jane M. (2018)
    Resistance training is rarely prescribed to enhance cardiovascular function; in fact, suggestions have been made that long-term resistance training may lead to chronic augmentations in carotid arterial stiffness and ...
  • Thumbnail

    Impaired myocardial function does not explain reduced left ventricular filling and stroke volume at rest or during exercise at high altitude 

    Stembridge, Mike; Ainslie, Philip; Hughes, Michael G.; Stöhr, Eric J.; Cotter, James D.; Tymko, Michael M.; Day, Trevor A.; Bakker, Akke; Shave, Rob (American Physiological Society, 2015-11-15)
    Impaired myocardial systolic contraction and diastolic relaxation have been suggested as possible mechanisms contributing to the decreased stroke volume (SV) observed at high altitude (HA). To determine whether intrinsic ...
  • Thumbnail

    The effect of training status on the associations between aortic reservoir pressure and left ventricular untwisting rate. 

    Samuel, Thomas Jake (2016-02-29)
    Athletic training status is known to influence cardiac function, although the mechanisms causing the changes are currently unknown. It is known that changes in arterial function can lead to cardiac adaptation and that ...

Browse

DSpace at Cardiff MetCommunities & CollectionsBy issue dateAuthorsTitlesSubjectsThis collectionBy issue dateAuthorsTitlesSubjects

My Account

Login

Statistics

Most Popular ItemsStatistics by CountryMost Popular Authors

DSpace software copyright © 2002-2015  DuraSpace
Contact us | Send feedback | Administrator