Repeated core temperature elevation induces conduit artery adaptation in humans
Pugh, Christopher J. A.
MetadataShow full item record
PURPOSE = Shear stress is a known stimulus to vascular adaptation in humans. However, it is not known whether thermoregulatory reflex increases in blood flow and shear can induce conduit artery adaptation. METHODS = Ten healthy young volunteers therefore underwent 8 weeks of 3 × weekly bouts of 30 min lower limb heating (40 °C) during which the upper body was not directly heated. Throughout each leg heating session, a pneumatic cuff was placed on one forearm and inflated to unilaterally restrict reflex-mediated blood flow responses. RESULTS = Each bout of leg heating significantly increased brachial artery shear rate in the uncuffed arm (96 ± 97 vs 401 ± 96 l/s, P < 0.01), whereas no change was apparent in the cuffed arm (83 ± 69 vs 131 ± 76 l/s, P = 0.67). Repeated episodic exposure to leg heating enhanced brachial artery endothelial function (measured by flow-mediated dilation) in the uncuffed arm from week 0 (5.2 ± 1.9 %) to week 4 (7.7 ± 2.6 %, P < 0.05), before returning to baseline levels by week 8. No adaptation was evident in the cuffed arm. CONCLUSIONS = We conclude that repeated increases in core temperature, induced via lower limb heating, resulted in upper limb conduit artery vascular adaptation which was dependent upon increases in shear stress. To our knowledge this is the first study to establish a beneficial systemic impact of thermoregulatory reflexes on conduit artery function in humans.
European Journal of Applied Physiology;
Carter, H.H., Spence, A.L., Atkinson, C.L., Pugh, C.J., Naylor, L.H. and Green, D.J. (2014) 'Repeated core temperature elevation induces conduit artery adaptation in humans', European journal of applied physiology, 114(4), pp.859-865.
Copy not available from this repository.
- Sport Research Groups 
Showing items related by title, author, subject and abstract.
Black, Jane M. (2018)Resistance training is rarely prescribed to enhance cardiovascular function; in fact, suggestions have been made that long-term resistance training may lead to chronic augmentations in carotid arterial stiffness and ...
Differential impact of water immersion on arterial blood flow and shear stress in the carotid and brachial arteries of humans Carter, H.C; Spence, A.L; Ainslie, Philip; Pugh, Christopher J. A.; Naylor, L.H.; Green, D.J. (Wiley Periodicals, Inc., 2017-05-30)Arterial shear stress is a potent stimulus to vascular adaptation in humans. Typically, increases in retrograde shear have been found to acutely impair vascular function while increases in antegrade shear enhance function. ...
Ventricular structure, function and mechanics at high altitude: chronic remodelling in Sherpa verses short-term lowlander adaptation. Unknown author (American Physiological Society, 2014-08-01)Short-term, high-altitude (HA) exposure raises pulmonary artery systolic pressure (PASP) and decreases left-ventricular (LV) volumes. However, relatively little is known of the long-term cardiac consequences of prolonged ...