The Impact of Remote Ischaemic Preconditioning on Cardiac Biomarker and Functional Response to Endurance Exercise
MetadataShow full item record
Remote ischemic preconditioning (RIPC; repeated short reversible periods of ischemia) protects the heart against subsequent ischemic injury. We explored whether RIPC can attenuate post‐exercise changes in cardiac troponin T (cTnT) and cardiac function in healthy individuals. In a randomized, crossover design, 14 participants completed 1‐h cycling time trials (TT) on two separate visits; preceded by RIPC (arms/legs, 4 × 5‐min 220 mmHg), or SHAM‐RIPC (20 mmHg). Venous blood was sampled before and 0‐, 1‐, and 3‐h post‐exercise to assess high sensitivity (hs‐)cTnT and brain natriuretic peptide (NT‐proBNP). Echocardiograms were performed at the same time points to assess left and right ventricular systolic (ejection fraction; EF and right ventricular fractional area change; RVFAC, respectively) and diastolic (early transmitral flow velocities; E) function. Baseline hs‐cTnT was not different between RIPC and SHAM. Post‐exercise hs‐cTnT levels were consistently lower following RIPC (18 ± 3 vs 21 ± 3; 19 ± 3 vs 23 ± 3; and 20 ± 2 vs 25 ± 2 ng/L at 0, 1 and 3‐h post‐exercise, respectively; P < 0.05). There was no main effect of time, trial, or interaction for NT‐proBNP and left ventricular EF or RVFAC (all P < 0.05). A main effect of time was evident for E which transiently declined immediately after exercise to a similar level in both trials (0.85 ± 0.04 vs 0.74 ± 0.04 m/s, respectively; P < 0.05). In summary, RIPC was associated with lower hs‐cTnT levels after exercise but there was no independent effect of RIPC for NT‐proBNP or LV systolic and diastolic function. The lower hs‐cTnT levels after RIPC suggests that further research should evaluate the role of ischemia in exercise‐induced elevation in hs‐cTnT.
Scandinavian Journal of Medicine & Science in Sports;
Cocking, S., Landman, T., Benson, M., Lord, R., Jones, H., Gaze, D., Thijssen, D.H. and George, K. (2017) 'The impact of remote ischemic preconditioning on cardiac biomarker and functional response to endurance exercise', Scandinavian Journal of Medicine & Science in Sports, 27(10), pp.1061-1069
Article published in Scandinavian Journal of Medicine & Science in Sports available at https://doi.org/10.1111/sms.12724
- Sport Research Groups 
Showing items related by title, author, subject and abstract.
Impaired myocardial function does not explain reduced left ventricular filling and stroke volume at rest or during exercise at high altitude Stembridge, Mike; Ainslie, Philip; Hughes, Michael G.; Stöhr, Eric J.; Cotter, James D.; Tymko, Michael M.; Day, Trevor A.; Bakker, Akke; Shave, Rob (American Physiological Society, 2015-11-15)Impaired myocardial systolic contraction and diastolic relaxation have been suggested as possible mechanisms contributing to the decreased stroke volume (SV) observed at high altitude (HA). To determine whether intrinsic ...
AMPK inactivation in mononuclear cells: a potential intracellular mechanism for exercise-induced immunosuppression Moir, Hannah; Butcher, Lee; Jones, Ken; Hughes, Michael G.; Neale, Huw; Jia, Huidong; Al-Ismaily, Zuleikha; Webb, Richard (NRC Research Press, 2008)There is much evidence that prolonged intense exercise suppresses the immune system. However, the intracellular biochemical mechanisms linking exercise and immunosuppression remain obscure. The purpose of this study was ...
The effect of alpha1-adrenergic blockade on post-exercise brachial artery flow-mediated dilatation at sea-level and high-altitude Tymko, Michael; Tremblay, Joshua; Howe, Connor; Willie, Christopher; Stembridge, Mike; Green, Daniel; Hoiland, Ryan; Subedi, Prajan; Anholm, James; Ainslie, Philip (Wiley, 2016-11-07)We examined the hypotheses that 1) at rest, endothelial function would be impaired at high- altitude compared to sea-level, 2) endothelial function would be reduced to a greater extent at sea-level compared to high-altitude ...