The effect of an aerobic exercise bout 24 h prior to each doxorubicin treatment for breast cancer on markers of cardiotoxicity and treatment symptoms: a RCT
Stöhr, Eric J.
MetadataDangos cofnod eitem llawn
Purpose = In rodents, a single exercise bout performed 24 h prior to a single doxorubicin treatment provides cardio-protection. This study investigated whether performing this intervention prior to every doxorubicin treatment for breast cancer reduced subclinical cardiotoxicity and treatment symptoms. Methods = Twenty-four women with early stage breast cancer were randomly assigned to perform a 30-min, vigorous-intensity treadmill bout 24 h prior to each of four doxorubicin-containing chemotherapy treatments or to usual care. Established echocardiographic and circulating biomarkers of subclinical cardiotoxicity, as well as blood pressure and body weight were measured before the first and 7–14 days after the last treatment. The Rotterdam symptom checklist was used to assess patient-reported symptoms. Results = The exercise and usual care groups did not differ in the doxorubicin-related change in longitudinal strain, twist, or cardiac troponin. However, the four total exercise bouts prevented changes in hemodynamics (increased cardiac output, resting heart rate, decreased systemic vascular resistance, p < 0.01) and reduced body weight gain, prevalence of depressed mood, sore muscles, and low back pain after the last treatment (p < 0.05) relative to the usual care group. No adverse events occurred. Conclusions = An exercise bout performed 24 h prior to every doxorubicin treatment did not have an effect on markers of subclinical cardiotoxicity, but had a positive systemic effect on hemodynamics, musculoskeletal symptoms, mood, and body weight in women with breast cancer. A single exercise bout prior to chemotherapy treatments may be a simple clinical modality to reduce symptoms and weight gain among women with breast cancer.
Breast Cancer Research and Treatment;
Kirkham, A.A., Eves, N.D., Shave, R.E., Bland, K.A., Bovard, J., Gelmon, K.A., Virani, S.A., McKenzie, D.C., Stöhr, E.J., Waburton, D.E. and Campbell, K.L. (2018) 'The effect of an aerobic exercise bout 24 h prior to each doxorubicin treatment for breast cancer on markers of cardiotoxicity and treatment symptoms: a RCT', Breast Cancer Research and Treatment, 167(3), pp.719-729
Dynodwr Gwrthrych Digidol (DOI)https://doi.org/10.1007/s10549-017-4554-4
Article published in Breast Cancer Research and Treatment available at https://doi.org/10.1007/s10549-017-4554-4
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Yn dangos eitemau sy’n perthyn drwy deitl, awdur, pwnc a chrynodeb.
Protective effects of acute exercise prior to doxorubicin on cardiac function of breast cancer patients: A proof-of-concept RCT Kirkham, Amy; Shave, Rob; Bland, Kelcey; Bovard, Josh; Eves, Neil; Gelmon, Karen; Virani, Sean; Stöhr, Eric J.; Warburton, Darren; Campbell, Kristin (Elsevier, 2017-07-14)Background: Preclinical studies have reported that a single treadmill session performed 24 h prior to doxorubicin provides cardio-protection. We aimed to characterize the acute change in cardiac function following an initial ...
UNDERSTANDING THE BENEFITS OF, AND PERCEPTIONS OF PHYSICAL ACTIVITY FOR THE BREAST CANCER PATIENT AND SURVIVOR IN ORDER TO PROMOTE INCREASED PARTICIPATION Hardiman, Annabelle (2013-02)Participation in physical activity appears to have many physiological and psychological benefits for patients and survivors of breast cancer. Whilst this is the case, breast cancer diagnosis has an inhibitory effect on ...
Jeevakumar, Nirusha (Cardiff Metropolitan University, 2017-06-01)Aim and background: The aim of this study was to determine the role of Daidzein in modulating the immune response in the breast cancer cell line, MDA-MB-231, through assessing its effect on the cytokines IL-6 and ...