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dc.contributor.authorKirkham, A.A.
dc.contributor.authorEves, N.D.
dc.contributor.authorShave, Rob
dc.contributor.authorBland, K.A.
dc.contributor.authorBovard, J.
dc.contributor.authorGelmon, K.A.
dc.contributor.authorVirani, S.A.
dc.contributor.authorMcKenzie, D.C.
dc.contributor.authorStöhr, Eric J.
dc.contributor.authorWaburton, D.E.
dc.contributor.authorCampbell, K.L.
dc.date.accessioned2018-03-19T13:11:34Z
dc.date.available2018-03-19T13:11:34Z
dc.date.issued2017-11-06
dc.identifierhttps://repository.cardiffmet.ac.uk/bitstream/id/31762/The%20effect%20of%20an%20aerobic%20exercise%20bout%2024%20hours%20prior%20to%20each%20doxorubicin%20treatment%20for%20breast%20cancer%20on%20markers%20of%20cardiotoxicity%20and%20treatment%20symptoms%20-%20a%20RCT.pdf
dc.identifier.citationKirkham, A.A., Eves, N.D., Shave, R.E., Bland, K.A., Bovard, J., Gelmon, K.A., Virani, S.A., McKenzie, D.C., Stöhr, E.J., Waburton, D.E. and Campbell, K.L. (2018) 'The effect of an aerobic exercise bout 24 h prior to each doxorubicin treatment for breast cancer on markers of cardiotoxicity and treatment symptoms: a RCT', Breast Cancer Research and Treatment, 167(3), pp.719-729
dc.identifier.issn0167-6806
dc.identifier.issn1573-7217 (online)
dc.identifier.urihttp://hdl.handle.net/10369/9405
dc.descriptionArticle published in Breast Cancer Research and Treatment available at https://doi.org/10.1007/s10549-017-4554-4
dc.description.abstractPurpose = In rodents, a single exercise bout performed 24 h prior to a single doxorubicin treatment provides cardio-protection. This study investigated whether performing this intervention prior to every doxorubicin treatment for breast cancer reduced subclinical cardiotoxicity and treatment symptoms. Methods = Twenty-four women with early stage breast cancer were randomly assigned to perform a 30-min, vigorous-intensity treadmill bout 24 h prior to each of four doxorubicin-containing chemotherapy treatments or to usual care. Established echocardiographic and circulating biomarkers of subclinical cardiotoxicity, as well as blood pressure and body weight were measured before the first and 7–14 days after the last treatment. The Rotterdam symptom checklist was used to assess patient-reported symptoms. Results = The exercise and usual care groups did not differ in the doxorubicin-related change in longitudinal strain, twist, or cardiac troponin. However, the four total exercise bouts prevented changes in hemodynamics (increased cardiac output, resting heart rate, decreased systemic vascular resistance, p < 0.01) and reduced body weight gain, prevalence of depressed mood, sore muscles, and low back pain after the last treatment (p < 0.05) relative to the usual care group. No adverse events occurred. Conclusions = An exercise bout performed 24 h prior to every doxorubicin treatment did not have an effect on markers of subclinical cardiotoxicity, but had a positive systemic effect on hemodynamics, musculoskeletal symptoms, mood, and body weight in women with breast cancer. A single exercise bout prior to chemotherapy treatments may be a simple clinical modality to reduce symptoms and weight gain among women with breast cancer.en_US
dc.language.isoenen_US
dc.publisherSpringeren_US
dc.relation.ispartofseriesBreast Cancer Research and Treatment;
dc.subjectDoxorubicin
dc.subjectBreast cancer
dc.subjectCardiotoxicity
dc.subjecttreatment symptoms
dc.titleThe effect of an aerobic exercise bout 24 h prior to each doxorubicin treatment for breast cancer on markers of cardiotoxicity and treatment symptoms: a RCTen_US
dc.typeArticleen_US
dc.typeacceptedVersion
rioxxterms.versionAMen_US
rioxxterms.versionofrecordhttps://doi.org/10.1007/s10549-017-4554-4
rioxxterms.licenseref.urihttp://www.rioxx.net/licenses/all-rights-reserveden_US
rioxxterms.licenseref.startdate2018-03-19
dc.refexceptionThere was a delay in securing the final peer-reviewed text
rioxxterms.publicationdate2017-11-06
dc.date.refFCD2018-03-19
rioxxterms.freetoread.startdate2018-11-06


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