Carotid artery longitudinal wall motion is associated with local blood velocity and left ventricular rotational, but not longitudinal, mechanics
Stöhr, Eric J.
American Physiological Society
MetadataShow full item record
Recent studies have identified a predictable movement pattern of the common carotid artery wall in the longitudinal direction. While there is evidence that the magnitude of this carotid artery longitudinal wall motion (CALM) is sensitive to cardiovascular health status, little is known about the determinants of CALM. The purpose of this integrative study was to evaluate the contribution of left ventricular (LV) cardiac motion and local blood velocity to CALM. Simultaneous ultrasound measurements of CALM, common carotid artery mean blood velocity (MBV), and left ventricular motion were performed in ten young, healthy individuals (6 males; 22 1 years). Peak anterograde CALM occurred at a similar time as peak MBV (18.57 3.98% vs. 18.53 2.81% cardiac cycle; t-test: P = 0.94; ICC: 0.79, P < 0.01). The timing of maximum retrograde CALM displacement was different, but related, to both peak apical (41.00 7.81% vs. 35.33 5.79% cardiac cycle; t-test: P < 0.01; ICC: 0.79, P < 0.01) and basal rotation (41.80 6.12% vs. 37.30 5.66% cardiac cycle; t-test: P < 0.01; ICC: 0.74, P < 0.01) with peak cardiac displacements preceding peak CALM displacements in both cases. The association between basal rotation and retrograde CALM was further supported by strong correlations between their peak magnitudes (r = 0.70, P = 0.02), whereas the magnitude of septal longitudinal displacement was not associated with peak CALM (r = 0.11, P = 0.77). These results suggest that the rotational mechanical movement of the LV base may be closely associated with longitudinal mechanics in the carotid artery. This finding may have important implications for interpreting the complex relationship between ventricular and vascular function.
Au, J.S., Ditor, D.S., MacDonald, M.J. and Stöhr, E.J. (2016) 'Carotid artery longitudinal wall motion is associated with local blood velocity and left ventricular rotational, but not longitudinal, mechanics', Physiological Reports, 4(14).
Article published open access in Physiological Reports available at https://doi.org/10.14814/phy2.12872
- Sport Research Groups 
Showing items related by title, author, subject and abstract.
Au, J.S.; Bochnak, P.A.; Valentino, S.E.; Cheng, J.L.; Stöhr, Eric J.; MacDonald, M.J. (Physiological Society, 2017-11-09)Carotid artery longitudinal wall motion (CALM) has recently attracted interest as an indicator of arterial health; however, the regulation of CALM is poorly understood. We conducted a series of studies aimed at manipulating ...
Differential impact of water immersion on arterial blood flow and shear stress in the carotid and brachial arteries of humans Carter, H.C; Spence, A.L; Ainslie, P.N; Pugh, Christopher J. A.; Naylor, L.H.; Green, D.J. (Wiley Periodicals, Inc., 2017-05-30)Arterial shear stress is a potent stimulus to vascular adaptation in humans. Typically, increases in retrograde shear have been found to acutely impair vascular function while increases in antegrade shear enhance function. ...
In vivo human cardiac shortening and lengthening velocity is region-dependent and not coupled with heart rate Stöhr, Eric J.; Stembridge, Mike; Esformes, Joseph I. (Wiley, 2015-05-01)New Findings •What is the central question of this study? Regulation of cardiac function is typically achieved by changes in heart rate (HR) and cardiac shortening velocity (strain rate; SR), but their interdependence ...