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dc.contributor.authorAu, J.S.
dc.contributor.authorBochnak, P.A.
dc.contributor.authorValentino, S.E.
dc.contributor.authorCheng, J.L.
dc.contributor.authorStöhr, Eric J.
dc.contributor.authorMacDonald, M.J.
dc.date.accessioned2018-03-19T13:45:58Z
dc.date.available2018-03-19T13:45:58Z
dc.date.issued2017-11-09
dc.identifier.citationAu, J.S., Bochnak, P.A., Valentino, S.E., Cheng, J.L., Stöhr, E.J. and MacDonald, M.J. (2018) 'Cardiac and haemodynamic influence on carotid artery longitudinal wall motion', Experimental Physiology, 103(1), pp.141-152
dc.identifier.issn0958-0670
dc.identifier.issn1469-445X (online)
dc.identifier.urihttp://hdl.handle.net/10369/9407
dc.descriptionArticle published in Experimental Physiology available at https://doi.org/10.1113/EP086621
dc.description.abstractCarotid artery longitudinal wall motion (CALM) has recently attracted interest as an indicator of arterial health; however, the regulation of CALM is poorly understood. We conducted a series of studies aimed at manipulating pulse pressure (PP), left ventricular (LV) motion and carotid shear rate, which have been previously suggested to regulate various components of CALM pattern and magnitude. To determine the regulatory influences on CALM, 15 healthy men (22 ± 2 years old) were exposed to three acute interventions: the serial subtraction test (SST); the cold pressor test (CPT); and exposure to sublingual nitroglycerine (NTG). The SST elicited increases in PP (P < 0.01), apical LV rotation (P < 0.01) and carotid shear rate (P < 0.01), with no changes in CALM (P > 0.05). Likewise, the CPT elicited increases in PP (P = 0.01), basal LV rotation (P = 0.04) and carotid shear rate (P = 0.01), with no changes in CALM (P > 0.05). Conversely, exposure to NTG elicited no change in PP (P = 0.22), basal (P = 0.65) or apical LV rotation (P = 0.45), but did decrease carotid shear rate (P < 0.01), without altering CALM (P > 0.05). Considerable individual variability in CALM responses prompted further analyses where all three interventions were pooled for change scores. Changes in LV basal rotation were related to changes in systolic retrograde CALM (B = −0.025, P = 0.03), whereas changes in carotid shear rate were related to changes in diastolic CALM displacement (B = 0.0009, P = 0.01). The interventions were underpinned by relationships between CALM and both LV basal rotation and local shear rate at the individual level, indicating that cardiac and haemodynamic factors may influence CALM in humans.en_US
dc.language.isoenen_US
dc.publisherPhysiological Societyen_US
dc.relation.ispartofseriesExperimental Physiology;
dc.titleCardiac and haemodynamic influence on carotid artery longitudinal wall motionen_US
dc.typeArticleen_US
dc.identifier.doihttps://doi.org/10.1113/EP086621
dcterms.dateAccepted2017-10-03
rioxxterms.versionVoRen_US
rioxxterms.licenseref.urihttp://www.rioxx.net/licenses/all-rights-reserveden_US
rioxxterms.licenseref.startdate2018-03-19
dc.refexceptionThere was a delay in securing the final peer-reviewed text
rioxxterms.freetoread.startdate2019-11-09


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