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dc.contributor.authorMcGregor, G.
dc.contributor.authorStöhr, Eric J.
dc.contributor.authorOxborough, D.
dc.contributor.authorKimani, P.
dc.contributor.authorShave, Rob
dc.date.accessioned2018-03-19T15:30:12Z
dc.date.available2018-03-19T15:30:12Z
dc.date.issued2018-01-31
dc.identifier.citationMcGregor, G., Stöhr, E.J., Oxborough, D., Kimani, P. and Shave, R. (2018) 'Effect of exercise training on left ventricular mechanics after acute myocardial infarction–an exploratory study', Annals of Physical and Rehabilitation Medicine, 61(3), pp.119-124
dc.identifier.issn1877-0657
dc.identifier.issn1877-0665 (online)
dc.identifier.urihttp://hdl.handle.net/10369/9416
dc.descriptionArticle published in Annals of Physical and Rehabilitation Medicine available at https://doi.org/10.1016/j.rehab.2018.01.003
dc.description.abstractBackground = Cardiac rehabilitation (CR) exercise training is beneficial after myocardial infarction (MI). Whilst the peripheral adaptations to training are well defined, little is known regarding the effect on left ventricular (LV) remodelling, particularly LV function. Efficient LV ejection and filling is achieved through deformation and rotation of the myocardium in systole and diastole – LV mechanics. The response of LV mechanics to CR exercise training in MI patients is unknown. Methods = In this observational exploratory study, 36 (of 40 enrolled) male, MI patients completed either 10-weeks of twice-weekly gym based cardiovascular exercise at 60–80% VO2peak (n = 18), or a non-exercise control period (n = 18). Cardiopulmonary exercise testing and speckle tracking echocardiography were performed at baseline and 10 weeks. Results = Compared to the non-exercise group, VO2peak improved with CR exercise training (Difference: +4.28 [95% CI: 1.34 to 7.23] ml.kg−1.min−1, P = 0.01). Neither conventional LV structural or functional indices, nor LV global longitudinal strain, significantly changed in either group. In contrast, LV twist and twist velocity decreased in the exercise group and increased in the non-exercise group (Difference: −3.95° [95% CI: −7.92 to 0.03°], P = 0.05 and −19.2°.s−1 [95% CI: −35.9 to −2.7°.s−1], P = 0.02, respectively). Conclusion = In MI patients who completed CR exercise training, LV twist and twist velocity decreased, whereas these parameters increased in patients who did not exercise. These preliminary data may indicate reverse LV functional remodelling and improved functional reserve. The assessment of LV twist may serve as an indicator of the therapeutic benefit of CR exercise training and should be investigated in larger trials.
dc.language.isoenen_US
dc.publisherElsevieren_US
dc.relation.ispartofseriesAnnals of Physical and Rehabilitation Medicine;
dc.subjectLongitudinal strain
dc.subjectleft ventricular twist;
dc.subjectleft ventricular remodelling
dc.titleEffect of exercise training on left ventricular mechanics after acute myocardial infarction-an exploratory studyen_US
dc.typeArticleen_US
dc.identifier.doihttps://doi.org/10.1016/j.rehab.2018.01.003
dcterms.dateAccepted2018-01-28
rioxxterms.versionAMen_US
rioxxterms.licenseref.urihttps://creativecommons.org/licenses/by-nc-nd/4.0/en_US
rioxxterms.licenseref.startdate2018-03-19
rioxxterms.freetoread.startdate2019-01-31


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