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dc.contributor.authorLord, Rachel
dc.contributor.authorUtomi, Victor
dc.contributor.authorOxborough, David
dc.contributor.authorCurry, Bryony
dc.contributor.authorBrown, Megan
dc.contributor.authorGeorge, Keith
dc.date.accessioned2018-06-11T14:26:35Z
dc.date.available2018-06-11T14:26:35Z
dc.date.issued2018-06-05
dc.identifier.citationLord, R.N., Utomi, V., Oxborough, D.L., Curry, B., Brown, M. and George, K.P. (2018) 'Left ventricular function and mechanics following prolonged endurance exercise: an update and meta-analysis with insights from novel techniques', European Journal of Applied Physiology, https://doi.org/10.1007/s00421-018-3906-zen_US
dc.identifier.issn1439-6327 (ESSN)
dc.identifier.urihttp://hdl.handle.net/10369/9639
dc.descriptionThis article was published in European Journal of Applied Physiology on 05 June 2018, available open access at https://doi.org/10.1007/s00421-018-3906-zen_US
dc.description.abstractBackground The cardiac consequences of undertaking endurance exercise are the topic of recent debate. The purpose of this review is to provide an update on a growing body of literature, focusing on left ventricular (LV) function following prolonged endurance exercise over 2 h in duration which have employed novel techniques, including myocardial speckle tracking, to provide a more comprehensive global and regional assessment of LV mechanics. Methods Prospective studies were filtered independently following a pre-set criteria, resulting in the inclusion of 27 studies in the analyses. A random-effects meta-analysis was used to determine the weighted mean difference and 95% confidence intervals (CI) of LV functional and mechanical data from pre-to-post-exercise. Narrative commentary was also provided where volume of available evidence precluded meta-analysis. Results A significant overall reduction in LV longitudinal strain (Ɛ) n = 22 (− 18 ± 1 to − 17 ± 1%; effect size (d) − 9: − 1 to − 0.5%), strain rate n = 10 (SR; d − 0.9: − 0.1.3 to − 0.5 l/s) and twist n = 5 (11.9 ± 2.2 to 8.7 ± 2.2°, d − 1: − 1.6 to − 0.3°) was observed following strenuous endurance exercise (range 120–1740 min) (P < 0.01). A smaller number of studies (n = 4) also reported a non-significant reduction in global circumferential and radial Ɛ (P > 0.05). Conclusion The meta-analysis and narrative commentary demonstrated that a reduction in LV function and mechanics is evident following prolonged endurance exercise. The mechanism(s) responsible for these changes are complex and likely multi-factorial in nature and may be linked to right and left ventricular interaction.en_US
dc.language.isoenen_US
dc.publisherSpringeren_US
dc.relation.ispartofseriesEuropean Journal of Applied Physiology;
dc.titleLeft ventricular function and mechanics following prolonged endurance exercise: an update and meta-analysis with insights from novel techniquesen_US
dc.typeArticleen_US
dc.identifier.doihttps://doi.org/10.1007/s00421-018-3906-z
dcterms.dateAccepted2018-05-26
rioxxterms.versionVoRen_US
rioxxterms.licenseref.urihttps://creativecommons.org/licenses/by/4.0/en_US
rioxxterms.licenseref.startdate2018-06-11


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