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dc.contributor.authorPugh, Christopher J. A.
dc.contributor.authorStone, Keeron J.
dc.contributor.authorStöhr, Eric J.
dc.contributor.authorMcDonnell, Barry
dc.contributor.authorThompson, Jane. E.S
dc.contributor.authorTalbot, Jack
dc.contributor.authorWakeham, Denis
dc.contributor.authorCockcroft, John R.
dc.contributor.authorShave, Rob
dc.date.accessioned2018-07-12T11:33:15Z
dc.date.available2018-07-12T11:33:15Z
dc.date.issued2018-06-29
dc.identifier.citationPugh, C.J., Stone, K.J., Stöhr, E.J., McDonnell, B.J., Thompson, J.E., Talbot, J.S., Wakeham, D.J., Cockcroft, J. and Shave, R., (2018) 'Carotid artery wall mechanics in young males with high cardiorespiratory fitness', Experimental Physiology.en_US
dc.identifier.issn0958-0670
dc.identifier.issn1469-445X
dc.identifier.urihttp://hdl.handle.net/10369/9687
dc.descriptionArticle published in Experimental Physiology on 29 June 2018 (online) available at https://doi.org/10.1113/EP087067en_US
dc.description.abstractThe influence of cardiorespiratory fitness (CRF) on arterial stiffness in young adults remains equivocal. Beyond conventional measures of arterial stiffness, 2D strain imaging of the common carotid artery (CCA) provides novel information related to the intrinsic properties of the arterial wall. Therefore, this study aimed to assess the effect of CRF on both conventional indices of CCA stiffness and 2D strain parameters, at rest and following a bout of aerobic exercise in young healthy males. Short‐axis ultrasound images of the CCA were recorded in 34 healthy men [22 years (95%CI, 19–22)] before, and immediately after 5‐minutes of aerobic exercise (40% VO2max). Images were analysed for arterial diameter, peak circumferential strain (PCS), and peak systolic and diastolic strain rates (S‐SR, D‐SR). Heart rate (HR), systolic and diastolic blood pressure (SBP, DBP) were simultaneously assessed and Petersons' elastic modulus (Ep) and Beta stiffness (β1) were calculated. Participants were separated post hoc into moderate and high fitness groups [VO2max: 48.9 ml.kg‐1 min‐1 (95%CI, 44.7–53.2) vs. 65.6 ml.kg‐1 min‐1 (95%CI, 63.1–68.1); P < 0.001]. Ep and β1 were similar between groups at baseline (P > 0.13) but were elevated in the moderate‐fitness group post‐exercise (P < 0.04). PCS and S‐SR were elevated in the high‐fitness group at both time‐points [3.0% (95%CI = 1.2, 4.9); P = 0.002; 0.401/s (95%CI = 0.085, 0.72); P = 0.02, respectively]. No group differences were observed in diameter, HR, SBP, DBP or D‐SR throughout the protocol (P > 0.05). High‐fit individuals exhibit elevated CCA PCS and S‐SR, which may reflect training‐induced adaptations that help to buffer the rise in pulse‐pressure and stroke volume during exercise.en_US
dc.language.isoenen_US
dc.publisherWileyen_US
dc.relation.ispartofseriesExperimental Physiology;
dc.titleCarotid artery wall mechanics in young males with high cardiorespiratory fitnessen_US
dc.typeArticleen_US
dc.identifier.doihttps://doi.org/10.1113/EP087067
dcterms.dateAccepted2018-06-28
rioxxterms.funderCardiff Metropolitan Universityen_US
rioxxterms.identifier.projectCardiff Metropolian (Internal)en_US
rioxxterms.versionAMen_US
rioxxterms.licenseref.urihttp://www.rioxx.net/licenses/under-embargo-all-rights-reserveden_US
rioxxterms.licenseref.startdate2019-06-29
rioxxterms.freetoread.startdate2019-06-29
rioxxterms.funder.project37baf166-7129-4cd4-b6a1-507454d1372een_US


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